Evidence map›Paper›PMID 31172169›Full record

ArticleThe American journal of clinical nutrition2019

A prospective study of artificially sweetened beverage intake and cardiometabolic health among women at high risk.

Stefanie N Hinkle, Shristi Rawal, Anne Ahrendt Bjerregaard, Thor I Halldorsson, Mengying Li, Sylvia H Ley, Jing Wu, Yeyi Zhu, Liwei Chen, Aiyi Liu and 6 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of clinical nutrition, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 4 pooled it
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 4 syntheses or guidelines pooled it, 26 citations in OpenAlex.

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  17. Non-nutritive Sweeteners and Glycaemic Control.Current atherosclerosis reports · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 8 institutions in 3 countries.

Stefanie N HinkleEpidemiology Branch, Bethesda, MD.
Shristi RawalDepartment of Nutritional Sciences, School of Health Professions, Rutgers University, Newark, NJ.
Anne Ahrendt BjerregaardCentre for Fetal Programming, Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
Thor I HalldorssonCentre for Fetal Programming, Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
Mengying LiEpidemiology Branch, Bethesda, MD.
Sylvia H LeyDepartment of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA.
Jing WuGlotech, Rockville, MD.
Yeyi ZhuDivision of Research, Kaiser Permanente Northern California, Oakland, CA.
Liwei ChenDepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, CA.
Aiyi LiuBiostatistics and Bioinformatics Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD.
Louise Groth GrunnetDepartment of Endocrinology, Diabetes and Bone-Metabolic Research Unit, Rigshospitalet, Copenhagen, Denmark.
Mohammad L RahmanEpidemiology Branch, Bethesda, MD.
Freja Bach KampmannDepartment of Endocrinology, Diabetes and Bone-Metabolic Research Unit, Rigshospitalet, Copenhagen, Denmark.
James L MillsEpidemiology Branch, Bethesda, MD.
Sjurdur F OlsenCentre for Fetal Programming, Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
Cuilin ZhangEpidemiology Branch, Bethesda, MD.
Statens Serum Institut · DKRigshospitalet · DKGlotech (United States) · USKaiser Permanente · USNational Institutes of Health · USRutgers, The State University of New Jersey · USTulane University · USUniversity of California, Los Angeles · US

Funding

Tulane COBRE in Cardiometabolic Diseases Clinical Research CoreP20GM109036 · NIGMS · TULANE UNIVERSITY OF LOUISIANA · PI Ning Liu · 2016 to 2026
$25.3M
NICHD NIH HHS HHSN275201000020CNICHD NIH HHS HHSN275201300026INICHD NIH HHS HHSN275201500003CNIGMS NIH HHS P20 GM109036
6 · The paper itself

Abstract

backgroundArtificially sweetened beverages (ASBs) are commonly consumed and recommended for individuals at high risk for cardiometabolic diseases; however, the health effects of ASBs remain contradictory. Given that cross-sectional analyses are subject to reverse causation, prospective studies with long-term follow-up are needed to evaluate associations between ASBs and cardiometabolic health, especially among high-risk individuals.

objectiveThe aim of this study was to examine associations of ASB intake and cardiometabolic health among high-risk women with prior gestational diabetes mellitus (GDM).

methodsWe included 607 women with GDM from the Danish National Birth Cohort (DNBC; 1996-2002) who completed a clinical exam 9-16 y after the DNBC pregnancy for the Diabetes & Women's Health (DWH) Study (2012-2014). We assessed ASB intake using FFQs completed during the DNBC pregnancy and at the DWH Study clinical exam. We examined cardiometabolic outcomes at the DWH clinical exam. We estimated percentage differences in continuous cardiometabolic markers and RRs for clinical endpoints in association with ASB intake both during pregnancy and at follow-up adjusted for prepregnancy BMI, diet, and lifestyle factors. Sensitivity analyses to account for reverse causation were performed.

resultsIn pregnancy and at follow-up, 30.4% and 36.4% of women regularly (≥2 servings/wk) consumed ASB, respectively. Consumption of ASBs, both during pregnancy and at follow-up, was associated with higher glycated hemoglobin (HbA1c), insulin, HOMA-IR, triglycerides, liver fat, and adiposity and with lower HDL at follow-up. After adjustment for covariates, particularly prepregnancy BMI, the majority of associations between ASB intake in pregnancy and outcomes at follow-up became null with the exception of HbA1c. ASB intake at follow-up (≥1 serving/d compared with <1 serving/mo) was associated with higher HbA1c (6.5%; 95% CI: 1.9, 11.3; P-trend = 0.007); however, associations were not upheld in sensitivity analyses for reverse causation.

conclusionsAmong Danish women with a history of GDM, ASB intake was not significantly associated with cardiometabolic profiles.

Indexed as

BeveragesAdultBody Mass IndexCardiovascular DiseasesCohort StudiesDenmarkDiabetes, GestationalDiabetes Mellitus, Type 2FemaleFollow-Up StudiesGlycated HemoglobinHumansMetabolic DiseasesPregnancyProspective StudiesRisk FactorsGlycated HemoglobinSweetening Agentsartificially sweetened beveragescardiometabolic healthdiabetesdietgestational diabetesnonnutritive sweetenersobesitysoda

Identifiers

PMID31172169
PMCPMC6599744
OpenAlexW2954256059

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.