ArticleTranslational vision science & technology2019
Representation of Central Endothelial Cell Density by Analysis of Single Best Specular Microscopy Image Regardless of Cell Size Variance.
Article in Translational vision science & technology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Postoperative Aqueous Flare in Diabetic Eyes and Fluidics-Related Surgical Parameters After Cataract Surgery Using the Eight-Chop Technique.Journal of clinical medicine · 2026Article
- Secondary childhood glaucoma in neurofibromatosis type 1: an unusual corneal leukoma case report.Frontiers in oncology · 2024Article
- Corneal Endothelial Cell Density in Normal Tension Glaucoma Compared to Healthy Controls.Journal of clinical medicine · 2022Article
- Corneal Endothelial Characteristics in Normal Chinese Han Children and Youngsters: A Study from the Specular Microscopy Descriptions.Disease markers · 2022Article
- Corneal endothelial cells and central corneal thickness in patients with neurofibromatosis type 1.Indian journal of ophthalmology · 2021Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe purpose of this study is to evaluate whether a single best image can represent central endothelial cell density (ECD) in corneas of differing cell size coefficient of variance (CV).
methodsFour hundred one healthy eyes but with variant CV values were enrolled. For each eye, three nonoverlapping central cornea endothelium images were obtained with Konan NSP-9900 specular microscope. ECD and CV were evaluated by two independent graders using the well-established Center method. Only corneas with high image quality rating (IQR) and ECD >800 cell/mm
resultsThe study sample includes a total of 278 eyes. High ECD agreement for the two independent graders (intraclass correlation coefficient [ICC] > 0.99), high ECD intragrader reproducibility (ICC > 0.95), low ECD variance (2.0% ± 1.6%, overall), no correlation between the ECD variation and the CV value (
conclusionsCV does not appear to be associated with ECD variance in the central cornea. TRANSLATIONAL RELEVANCE: This finding highlights that in healthy corneas but with high CV values, ECD can be reliably analyzed using one single image of best quality.
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