ArticleScientific reports2019
Histopathological factors help to predict lymph node metastases more efficiently than extra-nodal recurrences in submucosa invading pT1 colorectal cancer.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Additional staining for lymphovascular invasion is associated with increased estimation of lymph node metastasis in patients with T1 colorectal cancer: Systematic review and meta-analysis.Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society · 2024Pooled it
- Colon cancer: the 2023 Korean clinical practice guidelines for diagnosis and treatment.Annals of coloproctology · 2024Guideline
- Risk of recurrence after local resection of T1 rectal cancer: a meta-analysis with meta-regression.Surgical endoscopy · 2022Pooled it
- Tumor Budding as a Risk Factor for Lymph Node Metastasis and Local Recurrence in pT1 Colorectal Cancer: A Systematic Review and Meta-Analysis.Gastro hep advances · 2025Review
- Endoscopic resection alone as a potential treatment method for low-risk deep invasive T1 colorectal cancer.iGIE : innovation, investigation and insights · 2023Article
- Article
- Lymph node metastasis in T1 colorectal cancer: Risk factors and prediction model.Oncology letters · 2023Article
- Complete response to third-line treatment with trifluridine/tipiracil (TAS-102) in stage IV colon adenocarcinoma.Exploration of targeted anti-tumor therapy · 2023Article
- Endoscopic diagnosis and treatment of early colorectal cancer.Intestinal research · 2022Review
- Review
- Tumor Location as a Prognostic Factor in T1 Colorectal Cancer.Journal of the anus, rectum and colon · 2022Review
- Article
- A Liquid Biopsy Assay for Noninvasive Identification of Lymph Node Metastases in T1 Colorectal Cancer.Gastroenterology · 2021Article
- Tumour budding in solid cancers.Nature reviews. Clinical oncology · 2021Review
- The risk of lymph node metastasis in T1 colorectal cancer: new parameters to assess the degree of submucosal invasion.International journal of colorectal disease · 2021Review
- Prognostic utility of neutrophil-to-lymphocyte ratio in patients with metastatic colorectal cancer treated using different modalities.Current oncology (Toronto, Ont.) · 2020Article
- Pattern and Significance of Tumour Budding in Colorectal Carcinomas Using ITBCC Guidelines: a Low Resource Setting Practice Observation.Journal of gastrointestinal cancer · 2020Article
- Current Surgical Methods in Local Rectal Excision.Gastrointestinal tumorsReview
- Colorectal polyp classification and management of complex polyps for surgeon endoscopists.Canadian journal of surgery. Journal canadien de chirurgieReview
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Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The therapeutic management of patients with endoscopic resection of colorectal cancer invading the submucosa (i.e. pT1 CRC) depends on the balance between the risk of cancer relapse and the risk of surgery-related morbidity and mortality. The aim of our study was to report on the histopathological risk factors predicting lymph node metastases and recurrences in an exhaustive case series comprising every pT1 CRC (of adenocarcinoma subtype only) diagnosed in Finistère (France) during 5-years. For 312 patients with at least 46 months follow-up included in the digestive cancers registry database, histopathological factors required for risk stratification in pT1 CRC were reviewed. Patients were treated by endoscopic resection only (51 cases), surgery only (138 cases), endoscopic resection followed by surgery (102 cases) or transanal resection (21 cases). Lymph node metastases were diagnosed in 19 patients whereas 15 patients had an extra-nodal recurrence (7 local recurrences only, 4 distant metastases only and 4 combining local and distant recurrences). Four patients with distant metastases died of their cancer. Poor tumor differentiation, vascular invasion and high grade tumor budding on HES slides were notably identified as strong risk-factors of lymph node metastases but the prediction of extra-nodal recurrences (local, distant and sometimes fatal) was less obvious, albeit it was more frequent in patients treated by transanal resection than with other treatment strategies. Beyond good performances in predicting lymph node metastases and guiding therapeutic decision in patients with pT1 CRC, our study points that extra-nodal recurrence of cancer is more difficult to predict and requires further investigations.
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