ArticleScientific reports2019
Comparative genomics provides new insights into the remarkable adaptations of the African wild dog (Lycaon pictus).
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 38 citations in OpenAlex.
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- Coyotes can do 'puppy dog eyes' too: comparing interspecific variation inRoyal Society open science · 2024Article
- Complex Evolutionary History With Extensive Ancestral Gene Flow in an African Primate Radiation.Molecular biology and evolution · 2023Article
- Long-term Small Population Size, Deleterious Variation, and Altitude Adaptation in the Ethiopian Wolf, a Severely Endangered Canid.Molecular biology and evolution · 2023Article
- Comparative genomics uncovers the evolutionary history, demography, and molecular adaptations of South American canids.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Genome Sequencing of a Gray Wolf from Peninsular India Provides New Insights into the Evolution and Hybridization of Gray Wolves.Genome biology and evolution · 2022Article
- The successful reintroduction of African wild dogs (Lycaon pictus) to Gorongosa National Park, Mozambique.PloS one · 2021Article
- Adaptations to cursoriality and digit reduction in the forelimb of the African wild dog (PeerJ · 2020Article
- Hypercarnivorous teeth and healed injuries toPeerJ · 2020Article
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Authors and funding
6 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Within the Canidae, the African wild dog (Lycaon pictus) is the most specialized with regards to cursorial adaptations (specialized for running), having only four digits on their forefeet. In addition, this species is one of the few canids considered to be an obligate meat-eater, possessing a robust dentition for taking down large prey, and displays one of the most variable coat colorations amongst mammals. Here, we used comparative genomic analysis to investigate the evolutionary history and genetic basis for adaptations associated with cursoriality, hypercanivory, and coat color variation in African wild dogs. Genome-wide scans revealed unique amino acid deletions that suggest a mode of evolutionary digit loss through expanded apoptosis in the developing first digit. African wild dog-specific signals of positive selection also uncovered a putative mechanism of molar cusp modification through changes in genes associated with the sonic hedgehog (SHH) signaling pathway, required for spatial patterning of teeth, and three genes associated with pigmentation. Divergence time analyses suggest the suite of genomic changes we identified evolved ~1.7 Mya, coinciding with the diversification of large-bodied ungulates. Our results show that comparative genomics is a powerful tool for identifying the genetic basis of evolutionary changes in Canidae.
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