Evidence map›Paper›PMID 31171745›Full record

ArticleIET nanobiotechnology2019

Synthesis and characterisation of iron oxide nanoparticles conjugated with epidermal growth factor receptor (EGFR) monoclonal antibody as MRI contrast agent for cancer detection.

Zeinab Salehnia, Daryoush Shahbazi-Gahrouei, Abolfazl Akbarzadeh, Behzad Baradaran, Safar Farajnia, Mehran Naghibi

Open access · greenAbstract read
In one paragraph

Article in IET nanobiotechnology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.6field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
  2. Review
  3. Ligand-based active targeting strategies for cancer theranostics.Naunyn-Schmiedeberg's archives of pharmacology · 2023
    Review
  4. Review
  5. Review
  6. Review
  7. Antibody Nanocarriers for Cancer Management.Current opinion in biomedical engineering · 2021
    Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Zeinab SalehniaImmunology Research Centre, Tabriz University of Medical Sciences, Tabriz, Iran.
Daryoush Shahbazi-GahroueiDepartment of Medical Physics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. shahbazi@med.mui.ac.ir.
Abolfazl AkbarzadehDepartment of Medical Nanotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Behzad BaradaranImmunology Research Centre, Tabriz University of Medical Sciences, Tabriz, Iran.
Safar FarajniaDepartment of Chemical Engineering, Northeastern University, Boston, USA.
Mehran NaghibiDepartment of Anatomical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Tabriz University of Medical Sciences · IRIsfahan University of Medical Sciences · IRNortheastern University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study is to synthesise superparamagnetic iron oxide nanoparticles conjugated with anti-epidermal growth factor receptor monoclonal antibody (ANTI-EGFR-SPION) and investigate its physicochemical characterisation and biocompatibility as a targeted magnetic resonance imaging (MRI) contrast agent for the EGFR-specific detection in EGFR expressing tumour cells. These particles employed biocompatible polymers, poly(D,L-lactide-co-glycolide) (PLGA) and polyethylene glycol aldehyde (PEG-aldehyde), to increase the half-life of particles in circulation and reduce their side effects. The Fe

Indexed as

A549 CellsAntibodies, MonoclonalContrast MediaDrug CarriersErbB ReceptorsHumansMagnetic Resonance ImagingMagnetite NanoparticlesNeoplasmsParticle SizeAntibodies, MonoclonalContrast MediaDrug CarriersErbB ReceptorsMagnetite Nanoparticles

Identifiers

PMID31171745
PMCPMC8676663
OpenAlexW2912357545

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.