Evidence map›Paper›PMID 31171693›Full record

ArticleScience (New York, N.Y.)2019

Organoids-on-a-chip.

Sunghee Estelle Park, Andrei Georgescu, Dongeun Huh

Abstract read
In one paragraph

Article in Science (New York, N.Y.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 436 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
436citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

436 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Human cardiovascular organoids: Biomedical applications and ethical challenges.American heart journal plus : cardiology research and practice · 2026
    Review
  5. Article
  6. Review
  7. Review
  8. Organoids-on-a-Chip: An Integrating New Technology for Drug Development.International journal of molecular sciences · 2026
    Review
  9. Review
  10. Article
  11. Review
  12. Review
  13. A Colon Cancer Organoid-on-a-Chip Model for In Vitro Therapy Assessment.International journal of molecular sciences · 2026
    Article
  14. Review
  15. Review
  16. Review
  17. Review
  18. Article
  19. Organoid technology in cancer research.Molecular biomedicine · 2026
    Review
  20. Review

376 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sunghee Estelle ParkDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0002-2909-6507
Andrei GeorgescuDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0003-1612-3497
Dongeun HuhDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA. huhd@seas.upenn.edu.ORCID 0000-0002-5718-6884

Funding

Overall: Resource-based Center for Musculoskeletal Disorders Research (Overall Application)P30AR069619 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI LOUIS J SOSLOWSKY · 2016 to 2026
$9.1M
A vascularized 3D biomimetic for islet function and physiologyUC4DK104196 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI CHEN, CHRISTOPHER S, GADUE, PAUL J · 2014 to 2016
$5.1M
Probing the physics of chronic lung disease using microphysiological biomimicryDP2HL127720 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI HUH, DONGEUN · 2014 to 2014
$2.4M
Lung Host Defense in MicrogravityUG3TR002198 · NCATS · CHILDREN'S HOSP OF PHILADELPHIA · PI HUH, DONGEUN, WORTHEN, GEORGE SCOTT · 2017 to 2018
$1.4M
NCATS NIH HHS UG3 TR002198NHLBI NIH HHS DP2 HL127720NIAMS NIH HHS P30 AR069619NIDDK NIH HHS UC4 DK104196
6 · The paper itself

Abstract

Recent studies have demonstrated an array of stem cell-derived, self-organizing miniature organs, termed organoids, that replicate the key structural and functional characteristics of their in vivo counterparts. As organoid technology opens up new frontiers of research in biomedicine, there is an emerging need for innovative engineering approaches for the production, control, and analysis of organoids and their microenvironment. In this Review, we explore organ-on-a-chip technology as a platform to fulfill this need and examine how this technology may be leveraged to address major technical challenges in organoid research. We also discuss emerging opportunities and future obstacles for the development and application of organoid-on-a-chip technology.

Indexed as

Lab-On-A-Chip DevicesOrganoidsCell Culture TechniquesHumans

Identifiers

PMID31171693
PMCPMC7764943

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.