Evidence map›Paper›PMID 31171655›Full record

ArticleGenetics2019

A Novel Gene Underlies Bleomycin-Response Variation in

Shannon C Brady, Stefan Zdraljevic, Karol W Bisaga, Robyn E Tanny, Daniel E Cook, Daehan Lee, Ye Wang, Erik C Andersen

Open access · bronzeAbstract read
In one paragraph

Article in Genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 50 citations in OpenAlex.

  1. bioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. Beyond Rodents: Alternative Animal Models in Colorectal Cancer Research.International journal of molecular sciences · 2025
    Review
  4. Article
  5. Review
  6. Transcriptome analysis of the tardigrade Hypsibius exemplaris exposed to the DNA-damaging agent bleomycin.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2024
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Benzimidazoles cause lethality by inhibiting the function of Caenorhabditis elegans neuronal beta-tubulin.International journal for parasitology. Drugs and drug resistance · 2022
    Article
  14. Natural variation inGenome research · 2022
    Article
  15. Article
  16. Article
  17. Review
  18. Isolating Caenorhabditis elegans from the Natural Habitat.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Shannon C BradyMolecular Biosciences, Northwestern University, Evanston, Illinois 60208.ORCID 0000-0002-3043-1544
Stefan ZdraljevicMolecular Biosciences, Northwestern University, Evanston, Illinois 60208.ORCID 0000-0003-2883-4616
Karol W BisagaWeinberg College of Arts and Sciences, Northwestern University, Evanston, Illinois 60208.ORCID 0000-0002-7680-6022
Robyn E TannyMolecular Biosciences, Northwestern University, Evanston, Illinois 60208.ORCID 0000-0002-0611-3909
Daniel E CookThe Francis Crick Institute, London NW1 1ST, UK.ORCID 0000-0003-3347-562X
Daehan LeeMolecular Biosciences, Northwestern University, Evanston, Illinois 60208.ORCID 0000-0002-0546-8484
Ye WangMolecular Biosciences, Northwestern University, Evanston, Illinois 60208.ORCID 0000-0002-5423-6196
Erik C AndersenMolecular Biosciences, Northwestern University, Evanston, Illinois 60208 erik.andersen@northwestern.edu.ORCID 0000-0003-0229-9651
Northwestern University · USThe Francis Crick Institute · GB

Funding

CELLULAR &MOLECULAR BASIS OF DISEASE TRAINING PROGRAMT32GM008061 · NIGMS · NORTHWESTERN UNIVERSITY · PI CARTHEW, RICHARD W. · 1985 to 2022
$17.1M
Developing Capacity to Evaluate Training Programs via Development of Human, Institutional and Social CapitalT32GM008449 · NIGMS · NORTHWESTERN UNIVERSITY · PI LEONARD, JOSHUA NATHANIEL · 1993 to 2023
$7.8M
Discovery of conserved molecular mechanisms underlying population-wide variation in toxin responsesR01ES029930 · NIEHS · NORTHWESTERN UNIVERSITY · PI ANDERSEN, ERIK CHRISTIAN, BAUGH, LARRY RYAN · 2019 to 2023
$3.2M
NIEHS NIH HHS R01 ES029930NIGMS NIH HHS T32 GM008061NIGMS NIH HHS T32 GM008449
6 · The paper itself

Abstract

Bleomycin is a powerful chemotherapeutic drug used to treat a variety of cancers. However, individual patients vary in their responses to bleomycin. The identification of genetic differences that underlie this response variation could improve treatment outcomes by tailoring bleomycin dosages to each patient. We used the model organism

Indexed as

Quantitative Trait LociAnimalsAntibiotics, AntineoplasticBleomycinCaenorhabditis elegansCaenorhabditis elegans ProteinsDrug Resistance, NeoplasmNuclear ProteinsPolymorphism, GeneticQuantitative Trait, HeritableAntibiotics, AntineoplasticBleomycinCaenorhabditis elegans ProteinsNuclear Proteinsscb-1 protein, C elegansC. elegans bleomycindrug-responselinkage mappingQTL

Identifiers

PMID31171655
PMCPMC6707474
OpenAlexW2955632151

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.