Evidence map›Paper›PMID 31171579›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2019

The Role of the Anion in Salt (NaCl) Detection by Mouse Taste Buds.

Jennifer K Roebber, Stephen D Roper, Nirupa Chaudhari

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
10.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 99 citations in OpenAlex.

  1. Correlative Imaging Platform Linking Taste Cell Function to Molecular Identity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. Review
  9. Article
  10. Contribution of TRPC3-mediated CaPflugers Archiv : European journal of physiology · 2023
    Article
  11. Article
  12. Article
  13. Review
  14. Mimicking the Biological Sense of Taste In Vitro Using a Taste Organoids-on-a-Chip System.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Article
  15. Article
  16. Review
  17. Article
  18. Why Taste Is Pharmacology.Handbook of experimental pharmacology · 2022
    Article
  19. Taste Receptor Signaling.Handbook of experimental pharmacology · 2022
    Article
  20. Mechanisms for the Sour Taste.Handbook of experimental pharmacology · 2022
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 2 countries.

Jennifer K RoebberProgram in Neurosciences.ORCID 0000-0003-1027-8631
Stephen D RoperProgram in Neurosciences.ORCID 0000-0001-6049-8320
Nirupa ChaudhariProgram in Neurosciences, nchaudhari@med.miami.edu.ORCID 0000-0002-3883-5893
University of Miami · US

Funding

SIGNALING IN TASTE CELLSR01DC006308 · NIDCD · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI CHAUDHARI, NIRUPA · 2005 to 2020
$4.9M
A new method to measure taste bud functionR01DC007630 · NIDCD · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI ROPER, STEPHEN D. · 2006 to 2016
$3.1M
NIDCD NIH HHS R01 DC006308NIDCD NIH HHS R01 DC007630
6 · The paper itself

Abstract

How taste buds detect NaCl remains poorly understood. Among other problems, applying taste-relevant concentrations of NaCl (50-500 mm) onto isolated taste buds or cells exposes them to unphysiological (hypo/hypertonic) conditions. To overcome these limitations, we used the anterior tongue of male and female mice to implement a slice preparation in which fungiform taste buds are in a relatively intact tissue environment and stimuli are limited to the taste pore. Taste-evoked responses were monitored using confocal Ca

Indexed as

AmilorideAnimalsAnionsCalcium SignalingChloridesCholineFemaleFlavoring AgentsIon ChannelsMaleMiceNucleotides, CyclicSaccharinSodium ChlorideTasteTaste BudsAmilorideAnionsChloridesCholinecyclic guanosine monophosphate-adenosine monophosphateFlavoring AgentsIon ChannelsNucleotides, CyclicSaccharinSodium ChlorideamilorideCa2+ imagingfungiform taste budNaClsensory transductiontaste

Identifiers

PMID31171579
PMCPMC6687907
OpenAlexW2951359509

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.