Evidence map›Paper›PMID 31171577›Full record

ArticleDisease models & mechanisms2019

Anterior cleft palate due to Cbfb deficiency and its rescue by folic acid.

Safiye E Sarper, Toshihiro Inubushi, Hiroshi Kurosaka, Hitomi Ono Minagi, Yuka Murata, Koh-Ichi Kuremoto, Takayoshi Sakai, Ichiro Taniuchi, Takashi Yamashiro

Open access · goldAbstract read
In one paragraph

Article in Disease models & mechanisms, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Safiye E SarperDepartment of Orthodontics and Dentofacial Orthopedics, Graduate School of Dentistry, Osaka University, Osaka 565-0871, Japan.
Toshihiro InubushiDepartment of Orthodontics and Dentofacial Orthopedics, Graduate School of Dentistry, Osaka University, Osaka 565-0871, Japan.
Hiroshi KurosakaDepartment of Orthodontics and Dentofacial Orthopedics, Graduate School of Dentistry, Osaka University, Osaka 565-0871, Japan.
Hitomi Ono MinagiDepartment of Oral-facial Disorders, Osaka University Graduate School of Dentistry, Osaka 565-0871, Japan.
Yuka MurataDepartment of Orthodontics and Dentofacial Orthopedics, Graduate School of Dentistry, Osaka University, Osaka 565-0871, Japan.
Koh-Ichi KuremotoDepartment of Advanced Prosthodontics, Graduate School of Biomedical & Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan.ORCID 0000-0002-2265-4182
Takayoshi SakaiDepartment of Oral-facial Disorders, Osaka University Graduate School of Dentistry, Osaka 565-0871, Japan.
Ichiro TaniuchiLaboratory for Transcriptional Regulation, RIKEN Research Center for Allergy and Immunology, Yokohama 230-0045, Japan.
Takashi YamashiroDepartment of Orthodontics and Dentofacial Orthopedics, Graduate School of Dentistry, Osaka University, Osaka 565-0871, Japan yamashiro@dent.osaka-u.ac.jp.ORCID 0000-0002-4419-9643
Osaka Dental University · JPThe University of Osaka · JPHiroshima University · JPRIKEN Center for Integrative Medical Sciences · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Core binding factor β (Cbfb) is a cofactor of the Runx family of transcription factors. Among these transcription factors, Runx1 is a prerequisite for anterior-specific palatal fusion. It was previously unclear, however, whether Cbfb served as a modulator or as an obligatory factor in the Runx signaling process that regulates palatogenesis. Here, we report that Cbfb is essential and indispensable in mouse anterior palatogenesis. Palatal fusion in

Indexed as

AnimalsCleft PalateCore Binding Factor beta SubunitEpitheliumFolic AcidGene Expression Regulation, DevelopmentalMiceMice, Mutant StrainsModels, BiologicalMutationOrganogenesisPalatePhenotypeRNA, MessengerSTAT3 Transcription FactorTransforming Growth Factor beta3Cbfb protein, mouseCore Binding Factor beta SubunitFolic AcidRNA, MessengerSTAT3 Transcription FactorTransforming Growth Factor beta3Epithelial disintegrationPalatal fusionPalatogenesisRunx transcription factorsStat3Tgfb

Identifiers

PMID31171577
PMCPMC6602316
OpenAlexW2952201236

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.