Evidence map›Paper›PMID 31171458›Full record

ArticleJournal of stroke and cerebrovascular diseases : the official journal of National Stroke Association2019

Cognition and Quality of Life in Symptomatic Carotid Occlusion.

Marykay A Pavol, Kathryn Sundheim, Ronald M Lazar, Joanne R Festa, Randolph S Marshall

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Leptomeningeal collateral activation indicates severely impaired cerebrovascular reserve capacity in patients with symptomatic unilateral carotid artery occlusion.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Marykay A PavolStroke Division, Department of Neurology, Columbia University College of Physicians and Surgeons, New York, New York. Electronic address: mp2740@cumc.columbia.edu.
Kathryn SundheimStroke Division, Department of Neurology, Columbia University College of Physicians and Surgeons, New York, New York.
Ronald M LazarStroke Division, Department of Neurology, Columbia University College of Physicians and Surgeons, New York, New York.
Joanne R FestaDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York.
Randolph S MarshallStroke Division, Department of Neurology, Columbia University College of Physicians and Surgeons, New York, New York.

Funding

Blood Flow and Cognition in Asymptomatic Carotid Artery DiseaseR01NS076277 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LAZAR, RONALD M, MARSHALL, RANDOLPH S · 2012 to 2016
$2.0M
Study of Carotid Occlusion and Neurocognition (RECON)R01NS048212 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MARSHALL, RANDOLPH S · 2005 to 2009
$2.0M
The Brief Research in Aging and Interdisciplinary NeurosciencesT35AG044303 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Sachin Agarwal, Jennifer Jaie Manly · 2013 to 2026
$1.9M
NIA NIH HHS T35 AG044303NINDS NIH HHS R01 NS048212NINDS NIH HHS R01 NS076277
6 · The paper itself

Abstract

purposeCarotid occlusion may result in stroke, TIA, and cognitive reductions. Whether cognition predicts quality of life (QOL) for patients with carotid occlusion is unknown. Depression is also known to affect QOL. We examined whether cognition and depression predicted QOL in patients with carotid occlusive disease who have not had revascularization.

methodsPatients with unilateral carotid occlusion and history of TIA or a remote history of minor stroke were included. Patients underwent exam of memory, language, motor, and executive function skills and completed depression and QOL questionnaires (Center for Epidemiological Studies-Depression [CES-D], Stroke Specific QOL [SSQOL]). Deficits from remote stroke were assessed with the NIH Stroke Scale (NIHSS). Z-scores for cognitive tests were averaged (Cog-Z). The SSQOL scores were averaged across subgroup domains. Analyses of patients with all depression levels were followed by subgroup analyses for patients with minimal depression. Correlation findings were used to select the variables in a regression model to predict SSQOL.

resultsAmong 37 patients with all depression levels, QOL was predicted by deficits from remote stroke and depression (F(3, 36) = 21.15, P<.0005; NIHSS Beta = -.392, P = .001; CES-D Beta = -.577, P < .0005). Among 22 patients with minimal depression, QOL was predicted by cognitive and depression scores, (F(2,21) = 7.88, P = .003; Cog-Z Beta = .364, P = .05; CES-D Beta = -.495, P = .01).

conclusionsIn patients with carotid occlusive disease without major stroke and without revascularization, cognitive and depression scores independently predicted QOL. These data demonstrate the clinical relevance of cognitive and mood decline among patients with carotid occlusion.

Indexed as

AffectCognitionQuality of LifeAdultAgedCarotid StenosisCognition DisordersDepressionFemaleHumansIschemic Attack, TransientMaleMiddle AgedNeuropsychological TestsPrognosisRisk FactorsCarotid occlusioncognitiondepressionquality of life

Identifiers

PMID31171458
PMCPMC6679762

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.