Evidence map›Paper›PMID 31171165›Full record

ArticleTalanta2019

Capillary zone electrophoresis-tandem mass spectrometry for top-down proteomics using attapulgite nanoparticles functionalized separation capillaries.

Tingting Wang, Daoyang Chen, Rachele A Lubeckyj, Xiaojing Shen, Zhichang Yang, Elijah N McCool, Xiaoqiang Qiao, Liangliang Sun

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Talanta, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 10 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Tingting WangSchool of Materials and Chemical Engineering, Ningbo University of Technology, Ningbo 315211, China; Department of Chemistry, Michigan State University, 578 S Shaw Ln, East Lansing, MI 48824, USA.
Daoyang ChenDepartment of Chemistry, Michigan State University, 578 S Shaw Ln, East Lansing, MI 48824, USA.
Rachele A LubeckyjDepartment of Chemistry, Michigan State University, 578 S Shaw Ln, East Lansing, MI 48824, USA.
Xiaojing ShenDepartment of Chemistry, Michigan State University, 578 S Shaw Ln, East Lansing, MI 48824, USA.
Zhichang YangDepartment of Chemistry, Michigan State University, 578 S Shaw Ln, East Lansing, MI 48824, USA.
Elijah N McCoolDepartment of Chemistry, Michigan State University, 578 S Shaw Ln, East Lansing, MI 48824, USA.
Xiaoqiang QiaoDepartment of Chemistry, Michigan State University, 578 S Shaw Ln, East Lansing, MI 48824, USA; College of Pharmaceutical Sciences, Key Laboratory of Analytical Science and Technology of Hebei Province, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis, Ministry of Education, Hebei University, Baoding 071002, China.
Liangliang SunDepartment of Chemistry, Michigan State University, 578 S Shaw Ln, East Lansing, MI 48824, USA. Electronic address: lsun@chemistry.msu.edu.
Michigan State University · USHebei University · CN

Funding

Quantitative proteomics of Zebrafish embryos and blastomeresR01GM125991 · NIGMS · MICHIGAN STATE UNIVERSITY · PI SUN, LIANGLIANG · 2018 to 2022
$1.7M
NIGMS NIH HHS R01 GM125991
6 · The paper itself

Abstract

Attapulgite nanoparticles have good chemical properties and can be modified easily for broad applications. In this work, for the first time, attapulgite nanoparticles were employed to modify the inner wall of separation capillaries for capillary zone electrophoresis-tandem mass spectrometry (CZE-MS/MS)-based top-down proteomics. The attapulgite nanoparticles and the inner wall of a fused silica capillary were first functionalized with γ-methacryloxypropyl trimethoxysilane. Then the modified nanoparticles and acrylamide were copolymerized in the fused silica capillary with the assistance of azobisisobutyronitrile and heat. The incorporation of high-surface-area nanoparticles in the linear polyacrylamide (LPA) coating resulted in significantly lower electroosmotic mobility compared with the typical LPA coating (3.48 × 10

Indexed as

Attapulgite nanoparticlesCapillary zone electrophoresisEscherichia coliTandem mass spectrometryTop-down proteomics

Identifiers

PMID31171165
PMCPMC6557293
OpenAlexW2941270566

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.