Evidence map›Paper›PMID 31170957›Full record

ArticleBMC musculoskeletal disorders2019

LINC00311 is overexpressed in ankylosing spondylitis and predict treatment outcomes and recurrence.

Hongfa Zhong, Mingliang Zhong

Open access · goldAbstract read
In one paragraph

Article in BMC musculoskeletal disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Hongfa ZhongDepartment of orthopaedics, Ganzhou People's Hospital, No.16 Meiguang Avenue, Ganzhou City, Jiang Xi Province, 341000, People's Republic of China.
Mingliang ZhongDepartment of orthopaedics, Ganzhou People's Hospital, No.16 Meiguang Avenue, Ganzhou City, Jiang Xi Province, 341000, People's Republic of China. swmnne0069617@126.com.
Ganzhou People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLncRNA LINC00311 participates in osteoporosis, which shows inverse pathological changes to ankylosing spondylitis (AS), indicating that LINC00311 is also involved in AS.

methodsAll the participants were enrolled in Ganzhou People's Hospital between January 2016 and January 2018 after this study was approved by Ganzhou People's Hospital Ethics Committee. Disease activity determination, follow-up and RT-qPCR were carried out during the research.

resultsIn the present study we found that LINC00311 was upregulated in AS patients comparing to healthy controls, and upregulation of LINC00311 distinguished AS patients from healthy controls. LINC00311 expression levels were positively correlated with disease activity. Comparing to pre-treatment levels, LINC00311 expression level decreased significantly after treatment. During 2-year follow-up, patients with high levels of LINC00311 showed a significantly higher rate of rehospitalization.

conclusionsTherefore, LINC00311 is overexpressed in AS and predict treatment outcomes and recurrence.

Indexed as

AdultAnti-Inflammatory Agents, Non-SteroidalBiomarkersCase-Control StudiesFemaleFollow-Up StudiesHealthy VolunteersHumansLow Back PainMaleMiddle AgedPredictive Value of TestsPrognosisRecurrenceRNA, Long NoncodingSeverity of Illness IndexAnti-Inflammatory Agents, Non-SteroidalBiomarkersRNA, Long NoncodingAnkylosing spondylitislncRNA LINC00311Re-hospitalization

Identifiers

PMID31170957
PMCPMC6554900
OpenAlexW2948953175

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.