Evidence map›Paper›PMID 31170925›Full record

ArticleBMC nephrology2019

Joint associations of obesity and estimated GFR with clinical outcomes: a population-based cohort study.

Marcello Tonelli, Natasha Wiebe, Csaba P Kovesdy, Matthew T James, Scott W Klarenbach, Braden J Manns, Brenda R Hemmelgarn, Alberta Kidney Disease Network

Open access · goldAbstract read
In one paragraph

Article in BMC nephrology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Risk of Hospital Readmission among People with CKD: A Population-Based Cohort Study.Clinical journal of the American Society of Nephrology : CJASN · 2026
    Article
  2. Article
  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Marcello TonelliDepartment of Medicine, University of Calgary, 7th Floor, TRW Building, 3280 Hospital Drive NW, Calgary, Alberta, T2N 4Z6, Canada. cello@ucalgary.ca.
Natasha WiebeDepartment of Medicine, University of Alberta, Edmonton, Alberta, Canada.
Csaba P KovesdyCollege of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA.
Matthew T JamesDepartment of Medicine, University of Calgary, 7th Floor, TRW Building, 3280 Hospital Drive NW, Calgary, Alberta, T2N 4Z6, Canada.
Scott W KlarenbachDepartment of Medicine, University of Alberta, Edmonton, Alberta, Canada.
Braden J MannsDepartment of Medicine, University of Calgary, 7th Floor, TRW Building, 3280 Hospital Drive NW, Calgary, Alberta, T2N 4Z6, Canada.
Brenda R HemmelgarnDepartment of Medicine, University of Calgary, 7th Floor, TRW Building, 3280 Hospital Drive NW, Calgary, Alberta, T2N 4Z6, Canada.
Alberta Kidney Disease Network
University of Alberta · CAUniversity of Calgary · CAUniversity of Tennessee Health Science Center · US

Funding

CIHR
6 · The paper itself

Abstract

backgroundDespite the interrelationships between obesity, eGFR and albuminuria, few large studies examine how obesity modifies the association between these markers of kidney function and adverse clinical outcomes.

methodsWe examined the joint associations between obesity, eGFR and albuminuria on four clinical outcomes (death, end-stage renal disease [ESRD], myocardial infarction [MI], and placement in a long-term care facility) using a population-based cohort with procedures from Alberta. Obesity was defined by body mass index ≥35 kg/m

resultsWe studied 1,293,362 participants, of whom 171,650 (13.3%) had documented obesity (BMI ≥ 35 kg/m

conclusionsWe found significant interactions between obesity and eGFR and/or albuminuria on the likelihood of adverse outcomes including death and ESRD. Since obesity is common, risk prediction tools for people with CKD might be improved by adding information on BMI or other proxies for body size in addition to eGFR and albuminuria.

Indexed as

AlbuminuriaObesityRenal Insufficiency, ChronicAlbertaBiomarkersBody Mass IndexDisease ProgressionFemaleGlomerular Filtration RateHumansKidney Failure, ChronicKidney Function TestsMaleMiddle AgedPreventive Health ServicesRisk FactorsBiomarkersAlbuminuriaeGFRObesity

Identifiers

PMID31170925
PMCPMC6555725
OpenAlexW2948613022

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.