ArticleJournal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc2019
Zinc overload in weaned pigs: tissue accumulation, pathology, and growth impacts.
Article in Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 40 citations in OpenAlex.
- Dietary supplementation with coated zinc oxide enhanced growth performance by modulating systemic immunity and microbial composition in weaned pigs.Journal of animal science and technology · 2026Article
- Bis-glycinate bound zinc supplementation in sows modulates sows and piglets gut microbiota and reduces piglet diarrhea incidence.Scientific reports · 2026Article
- Bioresorbable RFID capsule for assessing medication adherence.Nature communications · 2026Article
- Effects of Tetrabasic Zinc Chloride as Alternative to High Doses of Zinc Oxide on Growth Performance, Nutrient Digestibility, Intestinal Morphology, Immune Function, and Gut Microbiota in Weaned Piglets.Animals : an open access journal from MDPI · 2025Article
- Comparative effects of replacing soybean meal in feeds with processed soybean meal on intestinal health and growth of nursery pigs when fed pharmacological level of zinc.Animal bioscience · 2025Article
- Impact of zinc oxide on gut health, immunity, and growth in weaned piglets: exploring potential modes of action.Frontiers in veterinary science · 2025Article
- Antibiotic Residues and Zinc Concentrations in the Livers and Kidneys of Portuguese Piglets-Relationship to Antibiotic and Zinc Resistance in Intestinal Escherichia coli.Biological trace element research · 2024Article
- The Mechanism of Zinc Oxide in Alleviating Diarrhea in Piglets after Weaning: A Review from the Perspective of Intestinal Barrier Function.International journal of molecular sciences · 2024Review
- Long-term inhaling ultrafine zinc particles increases cardiac wall stresses elevated by myocardial infarction.Biomedical engineering online · 2024Article
- Impact of zinc supplementation on phenotypic antimicrobial resistance of fecal commensal bacteria from pre-weaned dairy calves.Scientific reports · 2024Article
- Porous Zinc Oxide and Plant Polyphenols as a Replacement for High-Dose Zinc Oxide on Growth Performance, Diarrhea Incidence, Intestinal Morphology and Microbial Diversity of Weaned Piglets.Animals : an open access journal from MDPI · 2024Article
- Evaluation of a microencapsulated form of zinc oxide on weanling pig growth performance, fecal zinc excretion, and small intestinal morphology.Translational animal science · 2024Article
- Comparative efficacy of a novel Bacillus subtilis-based probiotic and pharmacological zinc oxide on growth performance and gut responses in nursery pigs.Scientific reports · 2023Article
- Evaluation of a Natural Phytogenic Formulation as an Alternative to Pharmaceutical Zinc Oxide in the Diet of Weaned Piglets.Animals : an open access journal from MDPI · 2023Article
- Determination of the optimal dietary zinc content for pigs between 10 and 30 kg body weight.Journal of animal science · 2023Article
- In vitro investigation of monoglycerides and zinc glycinate: anti-inflammatory and epithelial barrier function.Journal of animal science · 2023Article
- Post-weaning diarrhea and use of feedstuffs in pigs.Animal frontiers : the review magazine of animal agriculture · 2022Article
- Too Much of a Good Thing: Rethinking Feed Formulation and Feeding Practices for Zinc in Swine Diets to Achieve One Health and Environmental Sustainability.Animals : an open access journal from MDPI · 2022Review
- Bioavailability of Different Zinc Sources in Pigs 0-3 Weeks Post-Weaning.Animals : an open access journal from MDPI · 2022Article
- Determination of the Optimal Level of Dietary Zinc for Newly Weaned Pigs: A Dose-Response Study.Animals : an open access journal from MDPI · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Zinc oxide (ZnO) is commonly fed to pigs at pharmacologic concentrations (2,000-3,000 ppm) for the first 3 wk post-weaning to increase growth and reduce enteric bacterial disease. The safety of this high-dose treatment is assumed based upon lower bioavailability of ZnO compared to other common forms of Zn in feed; however, limited data are available regarding the specific serum and tissue concentrations of Zn expected in animals experiencing overload following feeding of excessive ZnO. Fifty-five 3-wk-old pigs were divided into 5 groups receiving various concentrations of ZnO (0-6,000 ppm) for 3 wk. Pigs receiving 6,000 ppm ZnO had higher mean pancreatic Zn concentrations (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.