Evidence map›Paper›PMID 31170808›Full record

ArticleAmerican journal of respiratory and critical care medicine2019

Electronic Cigarette Vapor with Nicotine Causes Airway Mucociliary Dysfunction Preferentially via TRPA1 Receptors.

Samuel Chung, Nathalie Baumlin, John S Dennis, Robert Moore, Sebastian F Salathe, Phillip L Whitney, Juan Sabater, William M Abraham, Michael D Kim, Matthias Salathe

Open access · greenAbstract read
In one paragraph

Article in American journal of respiratory and critical care medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed, 1 pooled it
9.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

85 citing papers in PubMed, 1 synthesis or guideline pooled it, 130 citations in OpenAlex.

  1. Pooled it
  2. Acute Effect of E-Cigarette Inhalation on Mucociliary Clearance in E-Cigarette Users.Journal of aerosol medicine and pulmonary drug delivery · 2024
    Trial
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. The role of TRPA1 in lung cancer.Translational lung cancer research · 2025
    Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article

25 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Samuel ChungDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Kansas.ORCID 0000-0002-4988-0606
Nathalie BaumlinDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Kansas.ORCID 0000-0002-5341-6785
John S DennisDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Kansas.
Robert MooreDivision of Pulmonary, Critical Care and Sleep Medicine, University of Miami School of Medicine, Miami, Florida; and.
Sebastian F SalatheDivision of Pulmonary, Critical Care and Sleep Medicine, University of Miami School of Medicine, Miami, Florida; and.
Phillip L WhitneyDivision of Pulmonary, Critical Care and Sleep Medicine, University of Miami School of Medicine, Miami, Florida; and.
Juan SabaterDepartment of Research, Mount Sinai Medical Center, Miami Beach, Florida.
William M AbrahamDepartment of Research, Mount Sinai Medical Center, Miami Beach, Florida.
Michael D KimDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Kansas.ORCID 0000-0003-2103-6603
Matthias SalatheDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Kansas.ORCID 0000-0001-9092-4861
University of Miami · USMount Sinai Medical Center · US

Funding

TRP-mediated airway inflammation by e-cigarette vapingR01HL139365 · NHLBI · UNIVERSITY OF KANSAS MEDICAL CENTER · PI SALATHE, MATTHIAS A · 2018 to 2021
$1.8M
Molecular mechanisms for E-cigarette vapor-induced mucociliary dysfunction: role of nicotinic acetylcholine and TRP receptorsF32HL140729 · NHLBI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI CHUNG, SAMUEL · 2018 to 2020
$200k
NHLBI NIH HHS F32 HL140729NHLBI NIH HHS R01 HL139365
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsCell Culture TechniquesCotinineE-Cigarette VaporElectronic Nicotine Delivery SystemsEpithelial CellsGanglionic StimulantsHumansMucociliary ClearanceNicotineSheepTRPA1 Cation ChannelVapingCotinineE-Cigarette VaporGanglionic StimulantsNicotineTRPA1 Cation ChannelTRPA1 protein, humanairway epitheliumelectronic nicotine delivery systemsmucociliary transportmucusTRPA1

Identifiers

PMID31170808
PMCPMC6888648
OpenAlexW2948348375

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.