Evidence map›Paper›PMID 31170642›Full record

ArticleBioorganic chemistry2019

Phototoxicity of 7-oxycoumarins with keratinocytes in culture.

Christophe Guillon, Yi-Hua Jan, Diane E Heck, Thomas M Mariano, Robert D Rapp, Michele Jetter, Keith Kardos, Marilyn Whittemore, Eric Akyea, Ivan Jabin and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioorganic chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Exploring the Potential of Supercritical Fluid Extraction ofAntioxidants (Basel, Switzerland) · 2023
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Christophe GuillonDepartment of Chemistry, Lehigh University, Bethlehem, PA 18015, USA. Electronic address: chg3@lehigh.edu.
Yi-Hua JanDepartment of Environmental and Occupational Health, Rutgers University School of Public Health, Piscataway, NJ 08854, USA.
Diane E HeckDepartment of Environmental Science, New York Medical College, Valhalla, NY 10595, USA.
Thomas M MarianoDepartment of Environmental and Occupational Health, Rutgers University School of Public Health, Piscataway, NJ 08854, USA.
Robert D RappDepartment of Chemistry, Lehigh University, Bethlehem, PA 18015, USA.
Michele JetterDepartment of Chemistry, Lehigh University, Bethlehem, PA 18015, USA.
Keith KardosDepartment of Chemistry, Lehigh University, Bethlehem, PA 18015, USA.
Marilyn WhittemoreBuckman Laboratories, 1256 N. McLean Blvd, Memphis, TN 38108, USA.
Eric AkyeaDepartment of Chemistry, Lehigh University, Bethlehem, PA 18015, USA.
Ivan JabinLaboratoire de Chimie Organique, Université Libre de Bruxelles, B-1050 Brussels, Belgium.
Jeffrey D LaskinDepartment of Environmental and Occupational Health, Rutgers University School of Public Health, Piscataway, NJ 08854, USA.
Ned D HeindelDepartment of Chemistry, Lehigh University, Bethlehem, PA 18015, USA.

Funding

UMDNJ/Rutgers University CounterACT Research Center of ExcellenceU54AR055073 · NIAMS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI HECK, DIANE E · 2006 to 2024
$71.4M
NIAMS NIH HHS U54 AR055073
6 · The paper itself

Abstract

Seventy-one 7-oxycoumarins, 66 synthesized and 5 commercially sourced, were tested for their ability to inhibit growth in murine PAM212 keratinocytes. Forty-nine compounds from the library demonstrated light-induced lethality. None was toxic in the absence of UVA light. Structure-activity correlations indicate that the ability of the compounds to inhibit cell growth was dependent not only on their physiochemical characteristics, but also on their ability to absorb UVA light. Relative lipophilicity was an important factor as was electron density in the pyrone ring. Coumarins with electron withdrawing moieties - cyano and fluoro at C

Indexed as

AnimalsCell ProliferationCells, CulturedCoumarinsDose-Response Relationship, DrugKeratinocytesMiceMolecular StructurePhotochemical ProcessesPhotosensitizing AgentsStructure-Activity Relationship7-oxycoumarinCoumarinsPhotosensitizing Agents7-hydroxycoumarins7-oxycoumarins8-MOPDNA photo-damageFurocoumarinsMethoxsalenPAM212 keratinocytesPhototoxicityPsoralens

Identifiers

PMID31170642
PMCPMC6656587

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.