ArticleiScience2019
Inefficient Secretion of Anti-sigma Factor FlgM Inhibits Bacterial Motility at High Temperature.
Article in iScience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- TheJournal of proteome research · 2026Article
- Twin Small RNAs and Divergent Fates: The Expansive Regulatory Networks of OmrA and OmrB.International journal of molecular sciences · 2025Review
- Control of flagellar gene expression by a chemotaxis receptor-like regulator in pathogenic Escherichia coli.The EMBO journal · 2025Article
- Laboratory Evolution Reveals Transcriptional Mechanisms Underlying Thermal Adaptation of Escherichia coli.Genome biology and evolution · 2025Article
- Temperature-dependent alterations in the proteome of the emergent fish pathogen Edwardsiella piscicida.Journal of fish diseases · 2025Article
- Genome organization, virulence genes, and temperature-dependent motility of an emerging pathogen,Frontiers in microbiology · 2025Article
- The bacterial flagellum as an object for optical trapping.Biophysical reviews · 2024Review
- MotGen: a closed-loop bacterial motility control framework using generative adversarial networks.Bioinformatics (Oxford, England) · 2024Article
- Constitutive Activation of RpoH and the Addition of L-arabinose Influence Antibiotic Sensitivity of PHL628Antibiotics (Basel, Switzerland) · 2024Article
- Unravelling the transcriptome response of Enterobacter sp. S-33 under varying temperature.Archives of microbiology · 2024Article
- Gene regulatory network inference using mixed-norms regularized multivariate model with covariance selection.PLoS computational biology · 2023Article
- Solonamides, a Group of Cyclodepsipeptides, Influence Motility in the Native Producer Photobacterium galatheae S2753.Applied and environmental microbiology · 2022Article
- Flagellotropic Bacteriophages: Opportunities and Challenges for Antimicrobial Applications.International journal of molecular sciences · 2022Review
- The Transcription of Flagella of EnteropathogenicMicroorganisms · 2022Article
- Review
- Multiple Drug-Induced Stress Responses Inhibit Formation of Escherichia coli Biofilms.Applied and environmental microbiology · 2020Article
- Flagellum-Mediated Mechanosensing and RflP Control Motility State of Pathogenic Escherichia coli.mBio · 2020Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Temperature is one of the key cues that enable microorganisms to adjust their physiology in response to environmental changes. Here we show that motility is the major cellular function of Escherichia coli that is differentially regulated between growth at normal host temperature of 37°C and the febrile temperature of 42°C. Expression of both class II and class III flagellar genes is reduced at 42°C because of lowered level of the upstream activator FlhD. Class III genes are additionally repressed because of the destabilization and malfunction of secretion apparatus at high temperature, which prevents secretion of the anti-sigma factor FlgM. This mechanism of repression apparently accelerates loss of motility at 42°C. We hypothesize that E. coli perceives high temperature as a sign of inflammation, downregulating flagella to escape detection by the immune system of the host. Secretion-dependent coupling of gene expression to the environmental temperature is likely common among many bacteria.
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