Evidence map›Paper›PMID 31170601›Full record

ReviewCurrent opinion in immunology2019

Remembering to remember: T cell memory maintenance and plasticity.

Kyla D Omilusik, Ananda W Goldrath

Abstract readReview
In one paragraph

Review in Current opinion in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed.

  1. KLF2 overrides the resident memory CD8 T cell differentiation program, in opposition to KLF3.Proceedings of the National Academy of Sciences of the United States of America · 2026
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  4. NR4A1 limits CD8Research square · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Kyla D OmilusikUniversity of California San Diego, Division of Biological Sciences, Section of Molecular Biology, 9500 Gilman Drive, La Jolla, CA 92093-0377, United States.
Ananda W GoldrathUniversity of California San Diego, Division of Biological Sciences, Section of Molecular Biology, 9500 Gilman Drive, La Jolla, CA 92093-0377, United States. Electronic address: agoldrath@ucsd.edu.

Funding

TF regulation of CD8 and CD4 T cell memory in both systemic and dermal infectionU19AI109976 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI CROTTY, SHANE P · 2014 to 2018
$10.5M
T cell maintenance: molecular mediators of the TCR-derived survival signalR01AI067545 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GOLDRATH, ANANDA W · 2006 to 2021
$6.1M
Regulation of T cell immunity to viral infectionR01AI072117 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GOLDRATH, ANANDA W · 2008 to 2022
$5.4M
T cell maintenance: molecular mediators of T cell differentiation and survivalR37AI067545 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ananda W Goldrath · 2022 to 2026
$3.0M
NIAID NIH HHS R01 AI067545NIAID NIH HHS R01 AI072117NIAID NIH HHS R37 AI067545NIAID NIH HHS U19 AI109976
6 · The paper itself

Abstract

Upon activation, naive T cells give rise to a heterogeneous cell population of effector and memory T cells that mediate antigen clearance and provide long-lived protection from rechallenge. Many of the transcriptional regulators that direct the differentiation of naive T cells to acquire the range of phenotypic and functional characteristics of effector and memory T cells have been described. However, the active programs that maintain the specific subsets of memory T cells are less clear. Here, we discuss recent studies that suggest effector and memory CD8

Indexed as

AnimalsCD8-Positive T-LymphocytesCell DifferentiationEpigenesis, GeneticEpigenomicsGene Expression RegulationHumansImmunologic MemoryLymphocyte ActivationT-Lymphocyte Subsets

Identifiers

PMID31170601
PMCPMC6612439

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.