ArticleNeuroImage2019
A simple sleep EEG marker in childhood predicts brain myelin 3.5 years later.
Article in NeuroImage, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- Tracing infant sleep neurophysiology longitudinally from 3 to 6 months: EEG insights into brain development.Npj biological timing and sleep · 2026Article
- A user's introduction to an algorithmic method to identify space-time profiles of sleep slow oscillations: dataset constraints, case-use examples, and open-source code.Sleep advances : a journal of the Sleep Research Society · 2026Article
- Linking gut microbiota rhythmicity to circadian maturation in infants.Scientific reports · 2025Article
- Infant sleep EEG features at 4 months as biomarkers of neurodevelopment at 18 months.Pediatric research · 2025Article
- Pediatric sleep electrophysiology: Using polysomnography in developmental cognitive neuroscience.Developmental cognitive neuroscience · 2025Review
- Sleep Across the Lifespan: A Neurobehavioral Perspective.Current sleep medicine reports · 2025Review
- The importance of sleep for the developing brain.Current sleep medicine reports · 2024Article
- Neuropsychology and Electroencephalography in Rural Children at Neurodevelopmental Risk: A Scoping Review.Pediatric reports · 2023Article
- Lack of association between behavioral development and simplified topographical markers of the sleep EEG in infancy.Neurobiology of sleep and circadian rhythms · 2023Article
- Association between sleep slow-wave activity and in-vivo estimates of myelin in healthy young men.NeuroImage · 2023Article
- The sleep and wake electroencephalogram over the lifespan.Neurobiology of aging · 2023Article
- Sleep as a protective factor of children's executive functions: A study during COVID-19 confinement.PloS one · 2023Article
- Contributions of memory and brain development to the bioregulation of naps and nap transitions in early childhood.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Relations between sleep patterns early in life and brain development: A review.Developmental cognitive neuroscience · 2022Review
- Article
- Nonrapid eye movement sleep characteristics and relations with motor, memory, and cognitive ability from infancy to preadolescence.Developmental psychobiology · 2021Review
- A skin-conformable wireless sensor to objectively quantify symptoms of pruritus.Science advances · 2021Article
- Spatio-temporal properties of sleep slow waves and implications for development.Current opinion in physiology · 2020Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
Epidemiological research reveals that insufficient sleep in children has negative cognitive and emotional consequences; however, the physiological underpinnings of these observations remain understudied. We tested the hypothesis that the topographical distribution of deep sleep slow wave activity during the childhood predicts brain white matter microstructure (myelin) 3.5 y later. Healthy children underwent sleep high-density EEG at baseline (n = 13; ages 2.4-8.0 y) and follow-up (n = 14; ages 5.5-12.2 y). At follow-up, myelin (myelin water fraction) and cortical morphology were also quantified. Our investigation revealed 3 main findings. (1) The Frontal/Occipital (F/O)-ratio at baseline strongly predicted whole brain myelin at follow-up. (2) At follow-up, the F/O-ratio was only minimally (negatively) linked to brain myelin. (3) Cortical morphology was not related to the F/O-ratio, neither at baseline nor at follow-up. Our results support the hypothesis that during child development EEG markers during sleep longitudinally predict brain myelin content. Data extend previous findings reporting a link between EEG markers of sleep need and cortical morphology, by supporting the hypothesis that sleep is a necessary component to underlying processes of brain, and specifically myelin, maturation. In line with the overarching theory that sleep contributes to neurodevelopmental processes, it remains to be investigated whether chronic sleep loss negatively affects white matter myelin microstructure growth during sensitive periods of development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.