Evidence map›Paper›PMID 31170400›Full record

ReviewNeuron2019

Universal Transform or Multiple Functionality? Understanding the Contribution of the Human Cerebellum across Task Domains.

Jörn Diedrichsen, Maedbh King, Carlos Hernandez-Castillo, Marty Sereno, Richard B Ivry

Abstract readReview
In one paragraph

Review in Neuron, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 157 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
157citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

157 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Pooled it
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  4. What neurological diseases tell us about procedural perceptual-motor learning? A systematic review of the literature.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023
    Pooled it
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  7. Trial
  8. Trial
  9. Cerebellar microcircuits enable robust evidence-based decisions through cortico-cerebellar coupling.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  10. Review
  11. Article
  12. Review
  13. The Cerebellar Connectome.Cerebellum (London, England) · 2026
    Article
  14. The Human Cerebellum Encodes Temporally Sensitive Reinforcement Learning Signals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
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  17. Review
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97 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jörn DiedrichsenBrain and Mind Institute, Western University London, ON N6A 5B7, Canada; Department of Statistical and Actuarial Sciences, Western University, London, ON N6A 5B7, Canada; Department of Computer Science, Western University, London, ON N6A 5B7, Canada. Electronic address: jdiedric@uwo.ca.
Maedbh KingDepartment of Psychology, University of California, Berkeley, CA 94720, USA.
Carlos Hernandez-CastilloBrain and Mind Institute, Western University London, ON N6A 5B7, Canada.
Marty SerenoDepartment of Psychology, San Diego State University, San Diego, CA 92182, USA.
Richard B IvryDepartment of Psychology, University of California, Berkeley, CA 94720, USA.

Funding

Embodied Decision Making: The Influence of Action Errors on Reinforcement LearningR01NS092079 · NINDS · UNIVERSITY OF CALIFORNIA BERKELEY · PI IVRY, RICHARD · 2015 to 2019
$1.7M
Specifying the constraints on cerebellar dependent sensorimotor adaptationR01NS105839 · NINDS · UNIVERSITY OF CALIFORNIA BERKELEY · PI IVRY, RICHARD · 2018 to 2019
$709k
NINDS NIH HHS R01 NS092079NINDS NIH HHS R01 NS105839
6 · The paper itself

Abstract

An impressive body of research over the past 30 years has implicated the human cerebellum in a broad range of functions, including motor control, perception, language, working memory, cognitive control, and social cognition. The relatively uniform anatomy and physiology of the cerebellar cortex has given rise to the idea that this structure performs the same computational function across diverse domains. Here we highlight evidence from the human neuroimaging literature that documents the striking functional heterogeneity of the cerebellum, both in terms of task-evoked activity patterns and, as measured under task-free conditions, functional connectivity with the neocortex. Building on these observations, we discuss the theoretical challenges these results present to the idea of a universal cerebellar computation and consider the alternative concept of multiple functionality, the idea that the same underlying circuit implements functionally distinct computations.

Indexed as

AttentionCerebellar CortexCerebellumCognitionFunctional NeuroimagingHumansLanguageMagnetic Resonance ImagingMemory, Short-TermMovementPerceptioncerebellumcognitionfMRIfunctional magnetic resonance imagingreviewuniversal transform

Identifiers

PMID31170400
PMCPMC6686189

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.