Observational studyAmerican journal of ophthalmology2019
Projection-Resolved Optical Coherence Tomography Angiography of the Peripapillary Retina in Glaucoma.
Observational study in American journal of ophthalmology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 65 citations in OpenAlex.
- Comparison of the Effects of Latanoprostene Bunod and Timolol on Retinal Blood Vessel Density: A Randomized Clinical Trial.American journal of ophthalmology · 2022Trial
- Axial Length-Associated Structural and Microvascular Retinal Changes in Myopia: A Combined OCT and OCTA Analysis.Translational vision science & technology · 2026Observational
- Comparison of the number of peripapillary perforating scleral vessels between glaucomatous eyes and healthy eyes.Scientific reports · 2025Article
- Anatomy of the Macular Ganglion Cell Layer Plexus on Projection-Resolved Optical Coherence Tomographic Angiography.Translational vision science & technology · 2025Article
- Glaucomatous Focal Perfusion Loss in the Macula Measured by Optical Coherence Tomographic Angiography.American journal of ophthalmology · 2024Article
- Impact of acquisition area on deep-learning-based glaucoma detection in different plexuses in OCTA.Scientific reports · 2024Article
- Cytomegalovirus-positive Posner-Schlossman syndrome: to compare differences in retinal vessel area density between the affected and non-affected eye using optical coherence tomography angiography.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2023Observational
- Sector-Based Regression Strategies to Reduce Refractive Error-Associated Glaucoma Diagnostic Bias When Using OCT and OCT Angiography.Translational vision science & technology · 2023Article
- Relationships of Macular Functional Impairment With Structural and Vascular Changes According to Glaucoma Severity.Investigative ophthalmology & visual science · 2023Article
- Longitudinal Observation of Retinal Response to Optic Nerve Transection in Rats Using Visible Light Optical Coherence Tomography.Investigative ophthalmology & visual science · 2023Article
- Evaluation of optic nerve head vessels density changes after phacoemulsification cataract surgery using optical coherence tomography angiography.International journal of ophthalmology · 2023Article
- Optical coherence tomographic angiography detects retinal vascular changes associated with pituitary adenoma.American journal of ophthalmology case reports · 2022Article
- Association of macular structure, function, and vessel density with foveal threshold in advanced glaucoma.Scientific reports · 2022Article
- Regression-Based Strategies to Reduce Refractive Error-Associated Glaucoma Diagnostic Bias When Using OCT and OCT Angiography.Translational vision science & technology · 2022Article
- Selective vulnerability of the intermediate retinal capillary plexus precedes retinal ganglion cell loss in ocular hypertension.Frontiers in cellular neuroscience · 2022Article
- The Impact of Superficial Vessel Density on Glaucoma Progression according to the Stage of Glaucoma.Journal of clinical medicine · 2021Article
- OCT Angiography Artifacts in Glaucoma.Ophthalmology · 2021Article
- Optical coherence tomographic angiography study of perfusion recovery after surgical lowering of intraocular pressure.Scientific reports · 2021Article
- Vessel Density Loss of the Deep Peripapillary Area in Glaucoma Suspects and Its Association with Features of the Lamina Cribrosa.Journal of clinical medicine · 2021Article
- Determinants of vessel defects in superficial and deep vascular layers in normal-tension glaucoma using optical coherence tomography angiography.Scientific reports · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo detect plexus-specific peripapillary retinal perfusion defects in glaucoma, using projection-resolved optical coherence tomography angiography (PR-OCTA).
designProspective cross-sectional study.
methodsOne eye each of 45 perimetric glaucoma participants and 37 age-matched normal participants were scanned using 4.5-mm OCTA scans centered on the disc. The PR-OCTA algorithm removed flow projection artifacts in OCT angiograms. Five en face OCTA slabs were analyzed: nerve fiber layer plexus (NFLP), ganglion cell layer plexus (GCLP), superficial vascular complex (SVC [NFLP + GCLP]), deep vascular complex (DVC), and all plexi combined. Peripapillary retinal capillary density (CD) and vessel density (VD) were calculated using a reflectance-compensated algorithm.
resultsFocal capillary dropout could be visualized more clearly in the NFLP than in the other slabs. The NFLP, SVC, and all-plexus CD in the glaucoma group were significantly lower (P < 0.001) than in the normal group, but no significant differences in GCLP-CD and DVC-CD appeared between the 2 groups. Both NFLP-CD and SVC-CD had excellent diagnostic accuracy, as measured by the area under the receiver operating characteristic curve (AROC = 0.981 and 0.976), correlation with visual field mean deviation (Pearson r = 0.819 and 0.831), and repeatability (intraclass correlation coefficients = 0.947 and 0.942). Performances of NFLP-VD and SVC-VD were similar to the corresponding CD parameters.
conclusionsIn this glaucoma group, reduction in perfusion was more pronounced in superficial layers of the peripapillary retina (NFLP and SVC) than in the deeper layers. Reflectance-compensated CD and VD parameters for both NFLP and SVC could be useful in the clinical management of glaucoma.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.