ArticlePloS one2019
Candida albicans white and opaque cells exhibit distinct spectra of organ colonization in mouse models of infection.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Ovoid cell is an inducible small-sized morphotype that enhances proliferation and antifungal drug tolerance in the human fungal pathogen Cryptococcus neoformans.PLoS pathogens · 2026Article
- Response ofmSphere · 2026Article
- Article
- Genetic and environmental control of parasexual reproduction in the pathogenicMicrobiology and molecular biology reviews : MMBR · 2025Review
- White-opaque switching inMicrobiology and molecular biology reviews : MMBR · 2024Review
- Review
- Strain background ofMicrobiology (Reading, England) · 2024Article
- Article
- Farnesol and phosphorylation of the transcriptional regulator Efg1 affect Candida albicans white-opaque switching rates.PloS one · 2023Article
- Role of themBio · 2021Article
- Intraspecies Transcriptional Profiling Reveals Key Regulators of Candida albicans Pathogenic Traits.mBio · 2021Article
- Comparative genomics of white and opaque cell states supports an epigenetic mechanism of phenotypic switching in Candida albicans.G3 (Bethesda, Md.) · 2021Article
- Partridge and embryonated partridge egg as new preclinical models for candidiasis.Scientific reports · 2021Article
- The Roles of Chromatin Accessibility in Regulating theJournal of fungi (Basel, Switzerland) · 2021Review
- Parasexuality ofFrontiers in cellular and infection microbiology · 2021Review
- An Opaque Cell-Specific Expression Program of Secreted Proteases and Transporters Allows Cell-Type Cooperation inGenetics · 2020Article
- A Set of Diverse Genes Influence the Frequency of White-Opaque Switching inG3 (Bethesda, Md.) · 2020Article
- Protein Acetylation/Deacetylation: A Potential Strategy for Fungal Infection Control.Frontiers in microbiology · 2020Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Candida albicans, a species of fungi, can thrive in diverse niches of its mammalian hosts; it is a normal resident of the GI tract and mucosal surfaces but it can also enter the bloodstream and colonize internal organs causing serious disease. The ability of C. albicans to thrive in these different host environments has been attributed, at least in part, to its ability to assume different morphological forms. In this work, we examine one such morphological change known as white-opaque switching. White cells are the default state of C. albicans, and most animal studies have been carried out exclusively with white cells. Here, we compared the proliferation of white and opaque cells in two murine models of infection and also monitored, using specially constructed strains, switching between the two states in the host. We found that white cells outcompeted opaque cells in many niches; however, we show for the first time that in some organs (specifically, the heart and spleen), opaque cells competed favorably with white cells and, when injected on their own, could colonize these organs. In environments where the introduced white cells outcompeted the introduced opaque cells, we observed high rates of opaque-to-white switching. We did not observe white-to-opaque switching in any of the niches we examined.
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Registered trials
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