ArticlePLoS neglected tropical diseases2019
Increased growth ability and pathogenicity of American- and Pacific-subtype Zika virus (ZIKV) strains compared with a Southeast Asian-subtype ZIKV strain.
Article in PLoS neglected tropical diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 22 citations in OpenAlex.
- Mutations in the NS5 RdRp Domain of Zika and Dengue Viruses: Insights into Molecular Patterns in Inland Midwestern Brazil.Tropical medicine and infectious disease · 2026Article
- Reported circulation of Zika and re-circulation of Chikungunya in Dengue-endemic Dhaka, Bangladesh in 2024.PloS one · 2026Article
- The pathogenicity and potential risk evaluation of Zika virus to cause mysterious "Disease X": A brief report.Health science reports · 2024Article
- Characteristics, risk factors, and outcomes related to Zika virus infection during pregnancy in Northeastern Thailand: A prospective pregnancy cohort study, 2018-2020.PLoS neglected tropical diseases · 2024Article
- An overview of Zika virus genotypes and their infectivity.Revista da Sociedade Brasileira de Medicina Tropical · 2022Review
- Systemic inflammation, innate immunity and pathogenesis after Zika virus infection in cynomolgus macaques are modulated by strain-specificity within the Asian lineage.Emerging microbes & infections · 2021Article
- A mutation-mediated evolutionary adaptation of Zika virus in mosquito and mammalian host.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Leu-to-Phe substitution at prMScientific reports · 2021Article
- Embryonic Stage of Congenital Zika Virus Infection Determines Fetal and Postnatal Outcomes in Mice.Viruses · 2021Article
- Neural Stem Cells: What Happens When They Go Viral?Viruses · 2021Review
- Neuroinvasiveness of the MR766 strain of Zika virus in IFNAR-/- mice maps to prM residues conserved amongst African genotype viruses.PLoS pathogens · 2021Article
- Evaluation of Conserved RNA Secondary Structures within and between Geographic Lineages of Zika Virus.Life (Basel, Switzerland) · 2021Article
- Comparison of Zika virus inactivation methods for reagent production and disinfection methods.Journal of virological methods · 2021Article
- Dysregulation of Ephrin receptor and PPAR signaling pathways in neural progenitor cells infected by Zika virus.Emerging microbes & infections · 2020Article
- Congenital Zika Virus Infection in a Birth Cohort in Vietnam, 2017-2018.The American journal of tropical medicine and hygiene · 2020Article
- Immunological observations and transcriptomic analysis of trimester-specific full-term placentas from three Zika virus-infected women.Clinical & translational immunology · 2019Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated the growth properties and virulence in mice of three Zika virus (ZIKV) strains of Asian/American lineage, PRVABC59, ZIKV/Hu/Chiba/S36/2016 (ChibaS36), and ZIKV/Hu/NIID123/2016 (NIID123), belonging to the three distinct subtypes of this lineage. The American-subtype strain, PRVABC59, showed the highest growth potential in vitro, whereas the Southeast Asian-subtype strain, NIID123, showed the lowest proliferative capacity. Moreover, PRVABC59- and NIID123-infected mice showed the highest and lowest viremia levels and infectious virus levels in the testis, respectively, and the rate of damaged testis in PRVABC59-infected mice was higher than in mice infected with the other two strains. Lastly, ZIKV NS1 antigen was detected in the damaged testes of mice infected with PRVABC59 and the Pacific-subtype strain, ChibaS36, at 2 weeks post-inoculation and in the epididymides of PRVABC59-infected mice at 6 weeks post-inoculation. Our results indicate that PRVABC59 and ChibaS36 exhibit increased abilities to grow in vitro and in vivo and to induce testis damage in mice.
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