ArticleMicrobial genomics2019
Not all Pseudomonas aeruginosa are equal: strains from industrial sources possess uniquely large multireplicon genomes.
Article in Microbial genomics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Antibiofilm and antimetabolic effects of disinfectants on Pseudomonas aeruginosa strains isolated from cosmetic manufacturing environments.Applied microbiology and biotechnology · 2026Article
- Transcriptomic profiling ofMicrobial genomics · 2025Article
- Detection of the ST111 Global High-RiskCurrent issues in molecular biology · 2025Article
- Genomic characterization ofMicrobial genomics · 2025Article
- Carbapenem-ResistantAntibiotics (Basel, Switzerland) · 2025Review
- Genetic and virulence factors behind the success of high-riskFrontiers in microbiology · 2025Article
- Biocide-resistant Pseudomonas oleovorans isolated from water-based coatings used in construction.Journal of industrial microbiology & biotechnology · 2024Article
- Characteristics and phylogenetic distribution of megaplasmids and prediction of a putative chromid inComputational and structural biotechnology journal · 2024Article
- Niacinamide Antimicrobial Efficacy and Its Mode of Action via Microbial Cell Cycle Arrest.Microorganisms · 2024Article
- Eco-evolutionary dynamics of experimentalMicrobiology (Reading, England) · 2023Article
- A loophole in soap dispensers mediates contamination with Gram-negative bacteria.MicrobiologyOpen · 2023Article
- Identification of two distinct phylogenomic lineages and model strains for the understudied cystic fibrosis lung pathogenMicrobiology (Reading, England) · 2023Article
- Architecture of the biofilm-associated archaic Chaperone-Usher pilus CupE from Pseudomonas aeruginosa.PLoS pathogens · 2023Article
- Characterization of a Conjugative Multidrug Resistance IncP-2 Megaplasmid, pPAG5, from a Clinical Pseudomonas aeruginosa Isolate.Microbiology spectrum · 2022Article
- Non-Canonical Host Intracellular Niche Links to New Antimicrobial Resistance Mechanism.Pathogens (Basel, Switzerland) · 2022Review
- What makes a megaplasmid?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- Bacterial genome reductions: Tools, applications, and challenges.Frontiers in genome editing · 2022Review
- Comparative analysis reveals the modular functional structure of conjugative megaplasmid pTTS12 ofFrontiers in microbiology · 2022Article
- Emergence of Carbapenem-Resistant ST244, ST292, and ST2446Infection and drug resistance · 2022Article
- Potential Therapeutic Targets for Combination Antibody Therapy againstAntibiotics (Basel, Switzerland) · 2021Review
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13 authors.
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Abstract
Pseudomonas aeruginosa is a highly versatile, antibiotic-resistant Gram-negative bacterium known for causing opportunistic infections and contamination of industrial products. Despite extensive genomic analysis of clinical P. aeruginosa strains, no genomes exist for preservative-tolerant industrial strains. A unique collection of 69 industrial isolates was assembled and compared to clinical and environmental strains; 16 genetically distinct industrial strains were subjected to array tube genotyping, multilocus sequence typing and whole-genome sequencing. The industrial strains possessed high preservative tolerance and were dispersed widely across P. aeruginosa as a species, but recurrence of strains from the same lineage within specific industrial products and locations was identified. The industrial P. aeruginosa genomes (mean=7.0 Mb) were significantly larger than those of previously sequenced environmental (mean=6.5 Mb; n=19) and clinical (mean=6.6 Mb; n=66) strains. Complete sequencing of the P. aeruginosa industrial strain RW109, which encoded the largest genome (7.75 Mb), revealed a multireplicon structure including a megaplasmid (555 265 bp) and large plasmid (151 612 bp). The RW109 megaplasmid represented an emerging plasmid family conserved in seven industrial and two clinical P. aeruginosa strains, and associated with extremely stress-resilient phenotypes, including antimicrobial resistance and solvent tolerance. Here, by defining the detailed phylogenomics of P. aeruginosa industrial strains, we show that they uniquely possess multireplicon, megaplasmid-bearing genomes, and significantly greater genomic content worthy of further study.
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