Evidence map›Paper›PMID 31170010›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2019

Adenoviral gene transfer of a single-chain IL-23 induces psoriatic arthritis-like symptoms in NOD mice.

Rafael R Flores, Lana Carbo, Eun Kim, Montina Van Meter, Consuelo M Lopez De Padilla, Jing Zhao, Debora Colangelo, Matthew J Yousefzadeh, Luise A Angelini, Lei Zhang and 6 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Challenges and opportunities in animal models of psoriatic arthritis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2023
    Review
  3. Article
  4. IL-23 orchestrating immune cell activation in arthritis.Rheumatology (Oxford, England) · 2021
    Article
  5. Advances in Juvenile Spondyloarthritis.Current rheumatology reports · 2021
    Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 2 countries.

Rafael R FloresDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota, USA.
Lana CarboDepartment of Molecular Medicine, The Scripps Research Institute, Jupiter, Florida, USA.
Eun KimDepartment of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Montina Van MeterDepartment of Molecular Medicine, The Scripps Research Institute, Jupiter, Florida, USA.
Consuelo M Lopez De PadillaRehabilitation Medicine Research Center, Mayo Clinic, Rochester, Minnesota, USA.
Jing ZhaoDepartment of Molecular Medicine, The Scripps Research Institute, Jupiter, Florida, USA.
Debora ColangeloDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota, USA.
Matthew J YousefzadehDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota, USA.
Luise A AngeliniDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota, USA.
Lei ZhangDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota, USA.
Enrico PolaDepartment of Orthopaedic Surgery, Catholic University of Rome School of Medicine, Agostino Gemelli University Hospital, Rome, Italy.
Nam VoDepartment of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Christopher H EvansRehabilitation Medicine Research Center, Mayo Clinic, Rochester, Minnesota, USA.
Andrea GambottoDepartment of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Laura J NiedernhoferDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota, USA.
Paul D RobbinsDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota, USA.
Scripps Research Institute · USUniversity of Minnesota · USUniversity of Pittsburgh · USInstitute on Aging · USAgostino Gemelli University Polyclinic · ITMayo Clinic · USWinnMed · US

Funding

VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JOHN C. BYRD · 1988 to 2026
$158.0M
VARIABILITY, STABILITY & SMOOTHNESS OF WALKINGP30AG024827 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Caterina Rosano · 2004 to 2026
$28.6M
LMP and Bone HealingR01AR051456 · NIAMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ROBBINS, PAUL D. · 2008 to 2012
$1.7M
The role of cellular senescence in intervertebral disc agingR01AG044376 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI VO, NAM V · 2013 to 2017
$1.5M
NCI NIH HHS P30 CA047904NIAMS NIH HHS R01 AR051456NIA NIH HHS P30 AG024827NIA NIH HHS R01 AG044376
6 · The paper itself

Abstract

Previously, we demonstrated that intratumoral delivery of adenoviral vector encoding single-chain (sc)IL-23 (Ad.scIL-23) was able to induce systemic antitumor immunity. Here, we examined the role of IL-23 in diabetes in nonobese diabetic mice. Intravenous delivery of Ad.scIL-23 did not accelerate the onset of hyperglycemia but instead resulted in the development of psoriatic arthritis. Ad.scIL-23-treated mice developed erythema, scales, and thickening of the skin, as well as intervertebral disc degeneration and extensive synovial hypertrophy and loss of articular cartilage in the knees. Immunological analysis revealed activation of conventional T helper type 17 cells and IL-17-producing γδ T cells along with a significant depletion and suppression of T cells in the pancreatic lymph nodes. Furthermore, treatment with anti-IL-17 antibody reduced joint and skin psoriatic arthritis pathologies. Thus, these Ad.scIL-23-treated mice represent a physiologically relevant model of psoriatic arthritis for understanding disease progression and for testing therapeutic approaches.-Flores, R. R., Carbo, L., Kim, E., Van Meter, M., De Padilla, C. M. L., Zhao, J., Colangelo, D., Yousefzadeh, M. J., Angelini, L. A., Zhang, L., Pola, E., Vo, N., Evans, C. H., Gambotto, A., Niedernhofer, L. J., Robbins, P. D. Adenoviral gene transfer of a single-chain IL-23 induces psoriatic arthritis-like symptoms in NOD mice.

Indexed as

AdenoviridaeAnimalsArthritis, PsoriaticEnzyme-Linked Immunosorbent AssayFemaleFlow CytometryImmunohistochemistryInflammationInterleukin-17Interleukin-23Lymph NodesMiceMice, Inbred NODSkinInterleukin-17Interleukin-23adenovirusinterleukin-17interleukin-23psoriasistype 1 diabetes

Identifiers

PMID31170010
PMCPMC6662986
OpenAlexW2948926773

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.