SynthesisHuman brain mapping2019
Brain gray matter correlates of extraversion: A systematic review and meta-analysis of voxel-based morphometry studies.
Synthesis in Human brain mapping, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Abnormalities of intrinsic brain activity in late-life depression: a meta-analysis of resting-state functional imaging studies.Translational psychiatry · 2026Pooled it
- Extraversion and the resting brain: a coordinate-based meta-analysis of resting-state functional brain imaging studies.Brain structure & function · 2025Pooled it
- Gray matter structures associated with neuroticism: A meta-analysis of whole-brain voxel-based morphometry studies.Human brain mapping · 2021Pooled it
- Brain gray matter structures associated with trait impulsivity: A systematic review and voxel-based meta-analysis.Human brain mapping · 2021Pooled it
- Brain gray matter correlates of extraversion: A systematic review and meta-analysis of voxel-based morphometry studies.Human brain mapping · 2019Pooled it
- Mechanical Properties of the Cortex in Older Adults and Relationships With Personality Traits.Human brain mapping · 2025Article
- Network-based mapping and neurotransmitter architecture of brain gray matter correlates of extraversion.Frontiers in systems neuroscience · 2025Article
- Association of loneliness and grey matter volume in the dorsolateral prefrontal cortex: the mediating role of interpersonal self-support traits.Brain imaging and behavior · 2023Article
- Review: Defining Positive Emotion Dysregulation: Integrating Temperamental and Clinical Perspectives.Journal of the American Academy of Child and Adolescent Psychiatry · 2023Review
- Differential cortical activation patterns: pioneering sub-classification of tinnitus with and without hyperacusis by combining audiometry, gamma oscillations, and hemodynamics.Frontiers in neuroscience · 2023Article
- "Nothing to see here": No structural brain differences as a function of thePersonality neuroscience · 2022Review
- Emotional intelligence mediates the association between middle temporal gyrus gray matter volume and social anxiety in late adolescence.European child & adolescent psychiatry · 2021Article
- The Selective Dopamine D2 Blocker Sulpiride Modulates the Relationship Between Agentic Extraversion and Executive Functions.Cognitive, affective & behavioral neuroscience · 2021Article
- Neurostructural correlates of hope: dispositional hope mediates the impact of the SMA gray matter volume on subjective well-being in late adolescence.Social cognitive and affective neuroscience · 2020Article
- Neurostructural correlates of optimism: Gray matter density in the putamen predicts dispositional optimism in late adolescence.Human brain mapping · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Extraversion is a fundamental personality dimension closely related to an individual's life outcomes and mental health. Although an increasing number of studies have attempted to identify the neurostructural markers of extraversion, the results have been highly inconsistent. The current study aimed to achieve a comprehensive understanding of brain gray matter (GM) correlates of extraversion with a systematic review and meta-analysis approach. Our review showed relatively high interstudy heterogeneity among previous findings. Our meta-analysis of whole-brain voxel-based morphometry studies revealed that extraversion was stably associated with six core brain regions. Additionally, meta-regression analyses identified brain regions where the associations of extraversion with GM volume were modulated by gender and age. The relationships between extraversion and GM structures were discussed based on three extraversion-related functional systems. Furthermore, we explained the gender and age effects. Overall, our study is the first to reveal a comprehensive picture of brain GM correlates of extraversion, and the findings may be useful for the selection of targeted brain areas for extraversion interventions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.