Observational studyMedicine2019
Risk factors and impact of postoperative hyperglycemia in nondiabetic patients after cardiac surgery: A prospective study.
Observational study in Medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Systematic Review and Meta-Analysis of Risk Factors Associated with Postoperative Stress Hyperglycemia in Patients without Diabetes Following Cardiac Surgery.Reviews in cardiovascular medicine · 2025Pooled it
- The effect of a split-dose intravenous dexamethasone and a single high-dose on postoperative blood glucose after total joint arthroplasty: a randomized double-blind placebo-controlled trial.Journal of orthopaedic surgery and research · 2024Trial
- Development and validation of glucose trajectory subphenotypes in critically ill patients on early enteral nutrition: a retrospective cohort study.Scientific reports · 2026Article
- Intraoperative vascular ligation uncovers the role of tumor vasculature in Doege-Potter syndrome: a case report.Frontiers in oncology · 2026Article
- Association of stress hyperglycemia ratio with hospital mortality and acute kidney injury in patients with transfusion.Clinical and experimental nephrology · 2025Article
- Combined pathogenic characteristics to analyze susceptibility factors of postoperative pneumonia in patients undergoing cardiac surgery.Journal of cardiothoracic surgery · 2025Article
- A distributional reinforcement learning model for optimal glucose control after cardiac surgery.NPJ digital medicine · 2025Article
- Accuracy of Freestyle Libre continuous glucose monitoring system in critically ill patients after cardiac surgery.Journal of cardiothoracic surgery · 2025Review
- Risk Factors and Predictive Model for Stress Hyperglycemia After Cardiac Surgery in Non-Diabetic Patients.Journal of multidisciplinary healthcare · 2025Article
- Risk factors and clinical outcome of postoperative hyperglycemia after cardiac surgery with cardiopulmonary bypass.Frontiers in cardiovascular medicine · 2025Article
- Development of machine learning models for predicting postoperative hyperglycemia in non-diabetic gastric cancer patients: a retrospective cohort study analysis.Frontiers in endocrinology · 2025Article
- Association between hyperglycemia at ICU admission and postoperative acute kidney injury in patients undergoing cardiac surgery: Analysis of the MIMIC-IV database.Journal of intensive medicine · 2024Article
- Postoperative hyperglycemia among adult non-diabetic surgical patients at University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia.BMC anesthesiology · 2024Article
- Effect of stress hyperglycaemia on acute kidney injury in non-diabetic critically ill patients?International urology and nephrology · 2023Article
- The impact of postoperative blood glucose levels on complications and prognosis after esophagectomy in patients with esophageal cancer.Surgery today · 2023Article
- Comparison of spinal versus general anesthesia on the perioperative blood glucose levels in patients undergoing lower abdominal and pelvic surgery: a prospective cohort study, Ethiopia.Annals of medicine and surgery (2012) · 2023Article
- Effect of Intraoperative Magnesium Sulfate Administration on Blood Glucose Control following Total Joint Arthroplasty in Patients with Diabetes.Journal of clinical medicine · 2022Article
- Effect of CPB glucose levels on inflammatory response after pediatric cardiac surgery.BMC cardiovascular disorders · 2022Article
- An Update on Postoperative Cognitive Dysfunction Following Cardiac Surgery.Frontiers in psychiatry · 2022Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cardiac surgery induces a significant inflammatory hypermetabolic stress response, resulting in postoperative hyperglycemia in both preoperatively diabetic and nondiabetic patients. Such postoperative hyperglycemia has been associated with adverse outcomes in surgery and postsurgical recovery. Yet, while diabetes is a known risk factor for postoperative hyperglycemia, predictors of postoperative hyperglycemia among nondiabetics in the local Southeast Asian population remain unknown.We aim to investigate the predictors and outcomes associated with hyperglycemia after cardiac surgery among nondiabetics in the local Southeast Asian population. We analyzed data from 1602 nondiabetic adult patients undergoing elective cardiac surgery, from 2008 to 2010 at the 2 main heart centers in Singapore.Nondiabetic patients who developed postoperative hyperglycemia tended to be women, older, more obese, and hypertensive. Higher body mass index (BMI), age, aortic cross-clamp time, and blood transfusion were identified as independent risk factors of postoperative hyperglycemia. Postoperative hyperglycemia was also significantly associated with postoperative cardiac arrhythmias (26.9% vs 15.0%, P < .001), acute kidney injury (30.0% vs 20.1%, P < .001), longer intensive care unit (ICU) stay (46.7 ± 104.1 vs 37.2 ± 76.6 hours, P = .044) and longer hospitalization (11.5 ± 12.2 vs 9.6 ± 8.0 days, P < .001).Our study identified aortic cross-clamp time and blood transfusion as independent risk factors of postoperative hyperglycemia after cardiac surgery in nondiabetics. Similar to other studies, higher BMI and age were independent risk factors for postoperative hyperglycemia. Postoperative hyperglycemia was also associated with adverse perioperative outcomes and should thereby be avoided by treating modifiable risk factors identified in this study including reducing blood transfusion and aortic cross-clamp time. Our findings contribute to early risk stratification of nondiabetic patients who are at increased risk of postoperative hyperglycemia.
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