Observational studyMedicine2019
The cumulative venous thromboembolism incidence and risk factors in intensive care patients receiving the guideline-recommended thromboprophylaxis.
Observational study in Medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 4 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Risk factors of venous thromboembolism in ICU patients: a systematic review and meta-analysis.Annals of medicine · 2026Pooled it
- [S3 guideline on sepsis-prevention, diagnosis, therapy, and follow-up care-update 2025].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2025Guideline
- Incidence of acute pulmonary embolism in COVID-19 patients: Systematic review and meta-analysis.European journal of internal medicine · 2020Pooled it
- Thrombosis risk associated with COVID-19 infection. A scoping review.Thrombosis research · 2020Pooled it
- COVID-19 and coagulation: bleeding and thrombotic manifestations of SARS-CoV-2 infection.Blood · 2020Trial
- Contrast-enhanced ultrasound in critical care: a problem-solving approach.Frontiers in medicine · 2026Review
- Machine Learning-Based Early Prediction of Lower Extremity Deep Vein Thrombosis in the ICU: A Multicenter Study.Risk management and healthcare policy · 2026Article
- Deep vein thrombosis in severe community-acquired pneumonia patients undergoing thromboprophylaxis: Prevalence, risk factors, and outcome.Thrombosis journal · 2025Article
- Assessing Venous Thromboembolism Incidence and Risk Factors: a Narrative Review.Materia socio-medica · 2025Article
- Risk Assessment of Venous Thromboembolism among Septic Shock Patients: Single versus Concurrent Insertion of Central Venous Catheters.Medicina (Kaunas, Lithuania) · 2024Article
- Odds and associated factors for thrombosis development among Lebanese COVID-19 patients: a case-control retrospective study.Journal of pharmaceutical policy and practice · 2024Article
- The Benefits and Imperative of Venous Thromboembolism Risk Screening for Hospitalized Patients: A Systematic Review.Journal of clinical medicine · 2023Review
- Clinical characteristics of venous thromboembolism onset from severe high altitude pulmonary edema in plateau regions.Thrombosis journal · 2023Article
- The risk factors for deep venous thrombosis in critically ill older adult patients: a subgroup analysis of a prospective, multicenter, observational study.BMC geriatrics · 2022Observational
- A review of COVID-19-related thrombosis and anticoagulation strategies specific to the Asian population.Singapore medical journal · 2022Review
- The Incidence of Venous Thromboembolism in Critically Ill Patients with SARS-CoV-2 Infection Compared with Critically Ill Influenza and Community-Acquired Pneumonia Patients: A Retrospective Chart Review.Medical sciences (Basel, Switzerland) · 2022Article
- Incidence of proximal deep vein thrombosis in medical critical care patients.Thrombosis journal · 2022Article
- The incidence of venous thromboembolism in critically ill patients with COVID-19 compared with critically ill non-COVID patients.Irish journal of medical science · 2021Article
- Venous Thromboembolism in COVID-19 Compared to Non-COVID-19 Cohorts: A Systematic Review with Meta-Analysis.Journal of clinical medicine · 2021Review
- Prevalence, risk, and outcome of deep vein thrombosis in acute respiratory distress syndrome.Thrombosis journal · 2021Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Few prospective studies have reported the cumulative incidence of venous thromboembolism (VTE) in the intensive care unit (ICU), especially for patients receiving guideline-recommended VTE prophylaxis. We aimed to design a prospective observational study to investigate the cumulative incidence and risk factors of ICU-acquired VTE for those populations.We prospectively studied 281 consecutively included patients in the ICU at a single center. All patients provided informed consent. Patients received ultrasound evaluation and were followed for VTE before ICU discharge or within 28 days of ICU stay. The type of VTE thromboprophylaxis was also recorded for all patients. Variables from univariate analyses that were associated with VTE were included in the binary logistic regression analysis to determine VTE predictors. The cumulative VTE incidence with 95% confidence interval (CI) was estimated using Kaplan-Meier methods.Patients had a median age of 60 years (range, 18-89) and an acute physiology and chronic health evaluation II score of 17 (range, 4-36). Despite all patients receiving guideline-recommended thromboprophylaxis, the cumulative incidence of VTE at 7, 14, 21, and 28 days was 4.45% (95% CI 2.55-7.71), 7.14% (95% CI 4.61-10.97), 7.53% (95% CI 4.92-11.43), and 9.55% (95% CI 6.55-13.81), respectively. Central venous catheter use (P = .002, odds ratio [OR] = 4.50), Caprini score (P = .012, OR = 1.20), and ICU length of stay (P = .006, OR = 1.08) were independent risk factors related to the incidence of VTE for patients admitted to the ICU.Our prospective observational study found that the 28-day cumulative incidence of VTE was relatively high for patients admitted to the ICU, despite the use of guideline-recommended thromboprophylaxis. Patients with femoral central venous catheter, prolonged ICU length of stay, or a high Caprini score may have an increased risk of developing VTE.
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