ArticleMedicine2019
Diagnostic usefulness of molecular detection of Coxiella burnetii from blood of patients with suspected acute Q fever.
Article in Medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 41 citations in OpenAlex.
- Epidemiological investigation of a clinical case of Q fever in the Brazilian Amazon.Parasite epidemiology and control · 2026Article
- Early diagnostic performance of real-time PCR versus serology for murine typhus and Q fever in a public health setting.BMC infectious diseases · 2026Article
- Human and livestock exposure to Rift Valley fever virus and Coxiella burnetii in Eastern Ethiopia: a One Health cross-sectional study.Tropical medicine and health · 2026Article
- Spinal infection caused byFrontiers in medicine · 2026Article
- Molecular detection ofNew microbes and new infections · 2025Article
- One health approach based descriptive study on Coxiella burnetii infections in camels and abattoir workers in the United Arab Emirates.Scientific reports · 2025Article
- Coxiella burnetii Infections Identified by Molecular Methods, United States, 2006-2023.Emerging infectious diseases · 2025Article
- Risk perception, seroprevalence, and real-time PCR detection of Brucella among pyretic patients and domestic animals in Kwara State, Nigeria.Scientific reports · 2025Article
- Real-time PCR detection of Coxiella burnetii in dairy products in Kwara State, Nigeria: a public health concern.BMC veterinary research · 2025Article
- Case Report: Chronic Q fever mimicking malignancy and tuberculosis in a hemodialysis patient: multidisciplinary diagnosis guided by metagenomic next-generation sequencing.Frontiers in medicine · 2025Article
- Navigating Q fever: Current perspectives and challenges in outbreak preparedness.Open veterinary journal · 2024Review
- Acute Q fever in individuals with acute febrile illness & exposure to farm animals: Clinical manifestations & diagnostic approaches.The Indian journal of medical research · 2024Article
- Article
- The integration ofJournal of clinical microbiology · 2024Article
- A molecular toolbox for fast and convenient diagnosis of emerging and reemerging bacterial pathogens causing fever of intermediate duration.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2024Article
- Case report: a missed case of chronic Q fever infective endocarditis demonstrating the ongoing diagnostic challenges.Access microbiology · 2023Article
- Molecular diagnosis ofAnnals of medicine · 2021Article
- Acute Q Fever With Dermatologic Manifestations, Molecular Diagnosis, and No Seroconversion.Open forum infectious diseases · 2021Article
- Serological Evidence of Human Infection withVeterinary sciences · 2021Article
- Real-time PCR biochip for on-site detection of Coxiella burnetii in ticks.Parasites & vectors · 2021Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diagnosis of Q fever is difficult due to the lack of distinct clinical features that distinguish it from other febrile diseases. Serologic testing is the gold standard method for diagnosing Q fever, but antibody formation may not be detectable for 2 to 3 weeks from symptom onset, limiting early diagnosis. We thus evaluated the diagnostic utility of polymerase chain reaction (PCR) to detect Coxellia burnetii DNA in serum from patients with suspected acute Q fever.All adult patients with suspected acute Q fever were prospectively enrolled at a tertiary-care hospital from January 2016 through July 2018. Acute Q fever was diagnosed using clinical and laboratory criteria: fever with at least one other symptoms (myalgia, headache, pneumonia, or hepatitis) and single phase II immunoglobulin G (IgG) antibody titers ≥1:200 or immunoglobulin M (IgM) antibody titer ≥1:50 (probable), or a fourfold increase or seroconversion in phase II IgG antibody titers as measured by indirect immunofluorescence assays between paired samples (confirmed). We performed PCR targeting the transposase gene insertion element IS1111a of C. burnetii.Of the 35 patients with suspected acute Q fever, 16 (46%) were diagnosed with acute Q fever including 8 probable and 8 confirmed cases; the remaining 19 (54%) were diagnosed with other febrile diseases. The proportion of males diagnosed with Q fever was higher than those diagnosed with other febrile diseases (88% vs 44%, P = .03), but there were no other significant differences in clinical characteristics between the 2 groups. The Q fever PCR sensitivity was 81% (95% confidence interval [CI], 54-96), specificity was 90% (95% CI, 67-99), positive predictive value was 87% (95% CI, 63-96), and negative predictive value was 85% (95% CI, 67-94).Q fever PCR testing using blood from patients with suspected acute Q fever seems to be a rapid and useful test for early diagnosis of Q fever.
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