Evidence map›Paper›PMID 31169500›Full record

ArticleeLife2019

GPIHBP1 expression in gliomas promotes utilization of lipoprotein-derived nutrients.

Xuchen Hu, Ken Matsumoto, Rachel S Jung, Thomas A Weston, Patrick J Heizer, Cuiwen He, Norma P Sandoval, Christopher M Allan, Yiping Tu, Harry V Vinters and 13 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 18 citations in OpenAlex.

  1. GPIHBP1 on oligodendrocytes binds lipoprotein lipase within the human brain.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Review
  3. Endothelial Cell Regulation of Lipid Uptake During Feeding and Fasting.Arteriosclerosis, thrombosis, and vascular biology · 2026
    Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Tool to Resolve Distortions in Elemental and Isotopic Imaging.Journal of the American Chemical Society · 2024
    Article
  9. Article
  10. A protein of capillary endothelial cells, GPIHBP1, is crucial for plasma triglyceride metabolism.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Prognostic power of a lipid metabolism gene panel for diffuse gliomas.Journal of cellular and molecular medicine · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 4 institutions in 5 countries.

Xuchen HuDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, United States.ORCID 0000-0002-0944-624X
Ken MatsumotoVIB-KU Leuven Center for Cancer Biology (CCB), Leuven, Belgium.
Rachel S JungDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, United States.
Thomas A WestonDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, United States.
Patrick J HeizerDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, United States.
Cuiwen HeDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, United States.
Norma P SandovalDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, United States.
Christopher M AllanDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, United States.
Yiping TuDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, United States.
Harry V VintersDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, United States.
Linda M LiauDepartment of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, United States.
Rochelle M EllisonDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, United States.
Jazmin E MoralesDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, United States.
Lynn J BaufeldDepartment of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, United States.
Nicholas A BayleyDepartment of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, United States.
Liqun HeDepartment of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden.
Christer BetsholtzDepartment of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden.
Anne P BeigneuxDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, United States.
David A NathansonDepartment of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, United States.
Holger GerhardtVIB-KU Leuven Center for Cancer Biology (CCB), Leuven, Belgium.ORCID 0000-0002-3030-0384
Stephen G YoungDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, United States.ORCID 0000-0001-7270-3176
Loren G FongDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, United States.ORCID 0000-0002-4465-5290
Haibo JiangDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, United States.ORCID 0000-0002-2384-4826
University of California, Los Angeles · USUppsala University · SEMax Delbrück Center · DEVIB-KU Leuven Center for Cancer Biology · BE

Funding

UCLA-Caltech Medical Scientist Training ProgramT32GM008042 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI AJIJOLA, OLUJIMI A, DAWSON, DAVID WAYNE · 1985 to 2023
$29.9M
UCLA SPORE in Brain CancerP50CA211015 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Linda M Liau · 2017 to 2026
$25.2M
The Lipin Protein Family and Triglyceride Metabolism P01HL090553 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI YOUNG, STEPHEN G. · 2008 to 2018
$23.3M
Understanding the Influence of Lipid Homeostasis on T cell FunctionP01HL146358 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FONG, LOREN GI · 2019 to 2023
$11.7M
CARDIOVASCULAR SCIENTIST TRAINING PROGRAMT32HL007895 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SHIVKUMAR, KALYANAM, WATSON, KAROL E · 1998 to 2023
$9.2M
Refining Physiologic Mechanisms for Intravascular Triglyceride MetabolismR01HL087228 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BEIGNEUX, ANNE, FONG, LOREN GI · 2007 to 2024
$7.8M
Vascular Biology Training GrantT32HL069766 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LUSIS, ALDONS JAKE · 2002 to 2022
$7.4M
Investigating Mechanisms for Lipid Transport in Health and DiseaseR35HL139725 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI YOUNG, STEPHEN G. · 2018 to 2024
$6.1M
Defining mechanisms for lipid transport across capillary endothelial cellsR01HL125335 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI YOUNG, STEPHEN G. · 2015 to 2017
$1.2M
NCI NIH HHS Brain Tumor SPORE grant (P50-CA211015)NCI NIH HHS P50 CA211015NHLBI NIH HHS HL087228NHLBI NIH HHS HL090553NHLBI NIH HHS HL125335NHLBI NIH HHS P01 HL090553NHLBI NIH HHS P01 HL146358NHLBI NIH HHS R01 HL087228NHLBI NIH HHS R01 HL125335NHLBI NIH HHS R35 HL139725NHLBI NIH HHS T32 HL007895NHLBI NIH HHS T32 HL069766NIGMS NIH HHS GM008042NIGMS NIH HHS T32 GM008042NIH HHS Ruth L Kirschstein National Research Service Award (T32HL69766)
6 · The paper itself

Abstract

GPIHBP1, a GPI-anchored protein of capillary endothelial cells, binds lipoprotein lipase (LPL) within the subendothelial spaces and shuttles it to the capillary lumen. GPIHBP1-bound LPL is essential for the margination of triglyceride-rich lipoproteins (TRLs) along capillaries, allowing the lipolytic processing of TRLs to proceed. In peripheral tissues, the intravascular processing of TRLs by the GPIHBP1-LPL complex is crucial for the generation of lipid nutrients for adjacent parenchymal cells. GPIHBP1 is absent from the capillaries of the brain, which uses glucose for fuel; however, GPIHBP1 is expressed in the capillaries of mouse and human gliomas. Importantly, the GPIHBP1 in glioma capillaries captures locally produced LPL. We use NanoSIMS imaging to show that TRLs marginate along glioma capillaries and that there is uptake of TRL-derived lipid nutrients by surrounding glioma cells. Thus, GPIHBP1 expression in gliomas facilitates TRL processing and provides a source of lipid nutrients for glioma cells.

Indexed as

AnimalsBrainCapillariesCarbon IsotopesEndothelial CellsFatty AcidsGliomaGlucoseGlucose Transporter Type 1HumansLipoprotein LipaseLipoproteinsMice, Inbred C57BLReceptors, LipoproteinTriglyceridesCarbon-13Carbon IsotopesFatty AcidsGlucoseGlucose Transporter Type 1GPIHBP1 protein, humanGPI-HBP1 protein, mouseLipoprotein LipaseLipoproteinslipoprotein triglycerideReceptors, LipoproteinTriglyceridesbiochemistrycancer metabolismchemical biologyendothelial cellshumanhuman biologylipolysislipoprotein lipasemedicinemouseNanoSIMStriglycerides

Identifiers

PMID31169500
PMCPMC6594755
OpenAlexW2948383297

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.