Evidence map›Paper›PMID 31169224›Full record

ArticleJournal of cancer research and therapeutics

Impact of smoking on pathological features in oral cavity squamous cell carcinoma.

Karine A Al Feghali, Ahmed I Ghanem, Charlotte Burmeister, Steven S Chang, Tamer Ghanem, Christian Keller, Farzan Siddiqui

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PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cancer research and therapeutics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Guideline
  2. Prognostic impact of perineural invasion in oral cancer: a systematic review.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Karine A Al FeghaliDepartment of Radiation Oncology, Henry Ford Hospital, Detroit, MI, USA.
Ahmed I GhanemDepartment of Radiation Oncology, Henry Ford Hospital, Detroit, MI, USA.
Charlotte BurmeisterDepartment of Public Health Sciences, Henry Ford Hospital, Detroit, MI, USA.
Steven S ChangDepartment of Otolaryngology - Head and Neck Surgery, Henry Ford Hospital, Detroit, MI, USA.
Tamer GhanemDepartment of Otolaryngology - Head and Neck Surgery, Henry Ford Hospital, Detroit, MI, USA.
Christian KellerDepartment of Pathology, Henry Ford Hospital, Detroit, MI, USA.
Farzan SiddiquiDepartment of Radiation Oncology, Henry Ford Hospital, Detroit, MI, USA.

Funding

Genetic and Metabolic Determinants of 25(OH)D levels at Baseline and One Year: Findings from a Dose Ranging Vitamin D trialD43TW009118 · FIC · AMERICAN UNIVERSITY OF BEIRUT · PI FULEIHAN, GHADA ELHAJJ · 2012 to 2024
$2.5M
Fellow and Resident Radiation Oncology iNtensive Training in Imaging and Informatics to Empower Research Careers (FRONTI2ER)R25EB025787 · NIBIB · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI DAS, PRAJNAN, FULLER, CLIFTON DAVID · 2018 to 2022
$535k
FIC NIH HHS D43 TW009118NIBIB NIH HHS R25 EB025787
6 · The paper itself

Abstract

objectivesWe sought to determine whether smokers with oral cavity squamous cell carcinoma (OCSCC) have tumors with more adverse pathological features than in nonsmokers and whether or not these are predictive of outcomes. MATERIALS AND

methodsWe retrospectively identified 163 patients with American Joint Committee on Cancer stages I-IVa OCSCC diagnosed between 2005 and 2015 and treated with curative intent. A pathological risk score (PRS) was calculated using the National Comprehensive Cancer Network adverse risk factors: positive margin, extracapsular extension of lymph node metastases, pT3 or pT4 primary, N2 or N3 nodal disease, perineural invasion, and lymphovascular space invasion. Multivariable models were constructed to determine the independent predictors of overall survival (OS), recurrence-free survival (RFS), and PRS.

resultsA total of 108 (66.26%) were smokers and 55 nonsmokers. Three-year actuarial OS and RFS were 62% and 68% in smokers and 81% and 69% in nonsmokers, respectively (P = 0.06 and P = 0.63). Smokers were more likely to have advanced disease stage and tumors with aggressive pathological features than nonsmokers. Smokers had significantly worse PRS (mean ± standard deviation; 2.38 ± 2.19, median; 2.00) than nonsmokers (0.89 ± 1.21, 0.00) (P < 0.001). Older age, higher PRS, and smoking status were independent predictors of OS. Smoking or PRS did not predict for worse RFS. On multivariate analysis, independent predictors of PRS were smoking status and grade (P < 0.001).

conclusionIn patients with OCSCC, smokers have more aggressive disease as evidenced by more adverse pathological features than nonsmokers. Moreover, smoking is an independent predictor of OS but not RFS. The PRS is a significant predictor of OS and needs validation in the future studies.

Indexed as

AdultAgedBiopsyCarcinoma, Squamous CellCombined Modality TherapyFemaleHumansKaplan-Meier EstimateMaleMiddle AgedMouth NeoplasmsNeoplasm MetastasisNeoplasm StagingPrognosisProportional Hazards ModelsRetrospective StudiesHead and neck canceroral canceroral cavitypathologyprognosissmokingsquamous cell carcinomasurvivaltobacco

Identifiers

PMID31169224
PMCPMC7470189

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.