SynthesisJournal of postgraduate medicine
Patients with psoriasis have a higher risk of schizophrenia: A systematic review and meta-analysis of observational studies.
Synthesis in Journal of postgraduate medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- Specificity of environmental risk factors for schizophrenia, bipolar disorders, and depressive disorders - umbrella review.Psychological medicine · 2025Pooled it
- Comorbid health outcomes in patients with schizophrenia: an umbrella review of systematic reviews and meta-analyses.Molecular psychiatry · 2025Pooled it
- The Psychiatric Burden in Alopecia Areata: A Propensity-Matched Cohort Study.Dermatology and therapy · 2026Article
- Gut microbiota dysbiosis at the interface of neuropsychiatric disorders and their dermatological comorbidities.Gut microbes · 2025Review
- Psychiatric Comorbidities in Patients with Psoriasis: A 10-Year Retrospective Epidemiological Study from a Tertiary University Center in Northeastern Romania.Medicina (Kaunas, Lithuania) · 2025Article
- Causal relationships between schizophrenia and psoriasis: a two-sample Mendelian randomization study.BMC psychiatry · 2025Article
- Psoriasis Is Associated With Increased Risk of Psychiatric Disorders and Sexual Dysfunction in a Case-Control Study of 29,912 Patients.Dermatology practical & conceptual · 2024Article
- The link between psoriasis and other diseases based on epidemiological and genetic analyses.Postepy dermatologii i alergologii · 2023Review
- Comorbidities and Medication Use in Finnish Patients with Psoriasis: A Population-Based Registry Study.Acta dermato-venereologica · 2023Article
- Dopamine, Immunity, and Disease.Pharmacological reviews · 2023Review
- Schizophrenia Etiological Factors and Their Correlation with the Imbalance of the Immune System: An Update.Galen medical journal · 2023Review
- Severe Mental Illness Among Adults with Atopic Eczema or Psoriasis: Population-Based Matched Cohort Studies within UK Primary Care.Clinical epidemiology · 2023Article
- Schizophrenia, Human Leukocyte Antigen (HLA), and Herpes Viruses: Immunogenetic Associations at the Population Level.Neuroscience insights · 2023Article
- Article
- Immune marker levels in severe mental disorders: associations with polygenic risk scores of related mental phenotypes and psoriasis.Translational psychiatry · 2022Article
- Psoriasis and medical ramifications: A comprehensive analysis based on observational meta-analyses.Frontiers in medicine · 2022Article
- HLA-Cw1 and Psoriasis.American journal of clinical dermatology · 2021Review
- Immunoceptive inference: why are psychiatric disorders and immune responses intertwined?Biology & philosophy · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Objectives: Patients with psoriasis are known to be at a higher risk of several comorbidities, but little is known about their risk of developing schizophrenia. Methods: A systematic review and meta-analysis of cohort and case-control studies that reported relative risk, hazard ratio, odds ratio (OR), or standardized incidence ratio comparing risk of schizophrenia in patients with psoriasis versus subjects without psoriasis was conducted. Pooled OR and 95% confidence interval were calculated using random-effect, generic inverse-variance methods of DerSimonian and Laird. Results: A total of five studies (one retrospective cohort study and four case-control studies) with more than 6 million participants met the eligibility criteria and were included in this meta-analysis. The pooled OR of schizophrenia in patients with psoriasis versus subjects without psoriasis was 1.41 (95% confidence interval, 1.19-1.66). The statistical heterogeneity was low with an I2 of 33%. Conclusion: This systematic review and meta-analysis demonstrated a significantly increased risk of schizophrenia among patients with psoriasis.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.