ArticleBrain and behavior2019
Identification of key genes and upstream regulators in ischemic stroke.
Article in Brain and behavior, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- When Heroes Fall: Reduced Expression of Heat-Resistant Obscure Proteins in Ischemic Stroke.Neuromolecular medicine · 2025Article
- Combined transcriptomic and proteomic analyses reveal relevant myelin features in mice with ischemic stroke.Functional & integrative genomics · 2025Article
- Machine learning analysis of gene expression profiles of pyroptosis-related differentially expressed genes in ischemic stroke revealed potential targets for drug repurposing.Scientific reports · 2025Article
- Expression of PIM1/ASK1 Molecular Pathway Related Genes in Ischemic Cardiomyopathy.Cardiovascular & hematological disorders drug targets · 2025Article
- Identification of hypoxia- and immune-related biomarkers in patients with ischemic stroke.Heliyon · 2024Article
- Integrative multi-omics approach using random forest and artificial neural network models for early diagnosis and immune infiltration characterization in ischemic stroke.Frontiers in neurology · 2024Article
- Construction of a novel circRNA-miRNA-ferroptosis related mRNA network in ischemic stroke.Scientific reports · 2023Article
- Negative regulation of angiogenesis and the MAPK pathway may be a shared biological pathway between IS and epilepsy.PloS one · 2023Article
- Identification and validation of platelet-related diagnostic markers and potential drug screening in ischemic stroke by integrating comprehensive bioinformatics analysis and machine learning.Frontiers in immunology · 2023Article
- Investigating theOxidative medicine and cellular longevity · 2022Article
- Prediction of Mechanosensitive Genes in Vascular Endothelial Cells Under High Wall Shear Stress.Frontiers in genetics · 2021Article
- Identification of Dysregulated Mechanisms and Potential Biomarkers in Ischemic Stroke Onset.International journal of general medicine · 2021Article
- High-Density Lipoprotein Carries Markers That Track With Recovery From Stroke.Circulation research · 2020Article
- Identification of candidate genes in ischemic cardiomyopathy by gene expression omnibus database.BMC cardiovascular disorders · 2020Article
- Identification of key genes and upstream regulators in ischemic stroke.Brain and behavior · 2019Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionIschemic stroke (IS) causes severe neurological impairments and physical disabilities and has a high economic burden. Our study aims to identify the key genes and upstream regulators in IS by integrated microarray analysis.
methodsAn integrated analysis of microarray studies of IS was performed to identify the differentially expressed genes (DEGs) in IS compared to normal control. Based on these DEGs, we performed the functional annotation and transcriptional regulatory network constructions. Quantitative real-time polymerase chain reaction (qRT-PCR) was performed to verify the expression of DEGs.
resultsFrom two Gene Expression Omnibus datasets obtained, we obtained 1526 DEGs (534 up-regulated and 992 down-regulated genes) between IS and normal control. The results of functional annotation showed that Oxidative phosphorylation and Alzheimer's disease were significantly enriched pathways in IS. Top four transcription factors (TFs) with the most downstream genes including PAX4, POU2F1, ELK1, and NKX2-5. The expression of six genes (ID3, ICAM2, DCTPP1, ANTXR2, DUSP1, and RGS2) was detected by qRT-PCR. Except for DUSP1 and RGS2, the other four genes in qRT-PCR played the same pattern with that in our integrated analysis.
conclusionsThe dysregulation of these six genes may involve with the process of ischemic stroke (IS). Four TFs (PAX4, POU2F1, ELK1 and NKX2-5) were concluded to play a role in IS. Our finding provided clues for exploring mechanism and developing novel diagnostic and therapeutic strategies for IS.
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