ArticleAdvanced materials (Deerfield Beach, Fla.)2019
Scalable Fabrication of Porous Microchannel Nerve Guidance Scaffolds with Complex Geometries.
Article in Advanced materials (Deerfield Beach, Fla.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 81 citations in OpenAlex.
- Balancing topographical guidance and spatial capacity: Optimized spatial density of micropatterned filaments for enhanced peripheral nerve regeneration.Materials today. Bio · 2026Article
- Additive Manufacturing of Polyamide-6 Preforms for Scalable Thermal Drawing of Structured Fibers.Micromachines · 2026Article
- Bioprinting of live platelet-loaded nerve conduit using energy-dissipative hydrogel.Bioactive materials · 2026Article
- The interaction between oxidative stress and Schwann cells.Experimental biology and medicine (Maywood, N.J.) · 2026Review
- Engineering neural recovery: Micro/nano-structured materials for nerve regeneration.Materials today. Bio · 2025Review
- Foreign Body Reaction to Neural Implants: A Comparative Study of Polymer Toxicity and Tissue Response.Biosensors · 2025Article
- Potentially commercializable nerve guidance conduits for peripheral nerve injury: Past, present, and future.Materials today. Bio · 2025Review
- Flexible multimaterial fibers in modern biomedical applications.National science review · 2024Review
- Multilevel neurium-mimetic individualized graft via additive manufacturing for efficient tissue repair.Nature communications · 2024Article
- Graphene in 3D Bioprinting.Journal of functional biomaterials · 2024Review
- Repair and regeneration of peripheral nerve injuries that ablate branch points.Neural regeneration research · 2023Review
- 4D Optical fibers based on shape-memory polymers.Nature communications · 2023Article
- Bio-inspired microfluidics: A review.Biomicrofluidics · 2023Review
- Co-drawing of technical and high-performance thermoplastics with glasses via the molten core method.Scientific reports · 2023Article
- Engineering multifunctional bioactive citrate-based biomaterials for tissue engineering.Bioactive materials · 2023Review
- Micropattern-based nerve guidance conduit with hundreds of microchannels and stem cell recruitment for nerve regeneration.NPJ Regenerative medicine · 2022Article
- Biomechanical microenvironment in peripheral nerve regeneration: from pathophysiological understanding to tissue engineering development.Theranostics · 2022Review
- Nerve Guidance Conduits with Hierarchical Anisotropic Architecture for Peripheral Nerve Regeneration.Advanced healthcare materials · 2021Article
- Selectively Micro-Patternable Fibers via In-Fiber Photolithography.ACS central science · 2020Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
Microchannel scaffolds accelerate nerve repair by guiding growing neuronal processes across injury sites. Although geometry, materials chemistry, stiffness, and porosity have been shown to influence nerve growth within nerve guidance scaffolds, independent tuning of these properties in a high-throughput manner remains a challenge. Here, fiber drawing is combined with salt leaching to produce microchannels with tunable cross sections and porosity. This technique is applicable to an array of biochemically inert polymers, and it delivers hundreds of meters of porous microchannel fibers. Employing these fibers as filaments during 3D printing enables the production of microchannel scaffolds with geometries matching those of biological nerves, including branched topographies. Applied to sensory neurons, fiber-based porous microchannels enhance growth as compared to non-porous channels with matching materials and geometries. The combinatorial scaffold fabrication approach may advance the studies of neural regeneration and accelerate the development of nerve repair devices.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.