Evidence map›Paper›PMID 31168829›Full record

ArticleExperimental dermatology2019

A topical heparinoid-containing product improves epidermal permeability barrier homeostasis in mice.

Ye Yao, Pan Guo, Xiaoyue Feng, Chunping Shen, Junkai Huang, Jiechen Zhang, Peter M Elias, Lizhi Hu, Mao-Qiang Man

Abstract read
In one paragraph

Article in Experimental dermatology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ye YaoImmunology Department, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Tianjin Medical University, Tianjin, China.
Pan GuoImmunology Department, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Tianjin Medical University, Tianjin, China.
Xiaoyue FengImmunology Department, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Tianjin Medical University, Tianjin, China.
Chunping ShenDepartment of Dermatology, Beijing Children's Hospital, National Center for Children's Health, Capital Medical University, Beijing, China.
Junkai HuangImmunology Department, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Tianjin Medical University, Tianjin, China.
Jiechen ZhangDermatology Services, Veterans Affairs Medical Center and University of California, San Francisco, California, USA.
Peter M EliasDermatology Services, Veterans Affairs Medical Center and University of California, San Francisco, California, USA.
Lizhi HuImmunology Department, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Tianjin Medical University, Tianjin, China.
Mao-Qiang ManDermatology Services, Veterans Affairs Medical Center and University of California, San Francisco, California, USA.ORCID 0000-0002-0957-4903

Funding

Pathogenesis and Therapy of Ichthyosis in Disorders of Lipid MetabolismR01AR061106 · NIAMS · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI MAURO, THEODORA M · 2012 to 2022
$3.3M
National Natural Science Foundation of China NSFC 81573075 and 81301360Natural Science Foundation of Tianjin City 2013KY06NIAMS NIH HHS AR061106NIAMS NIH HHS R01 AR061106
6 · The paper itself

Abstract

Because of the importance of epidermal functions, including stratum corneum hydration and maintenance of permeability barrier homeostasis, in the pathogenesis of a variety of cutaneous and systemic disorders, a wide range of products has been developed to improve epidermal functions. However, the underlying mechanisms whereby certain products, including heparinoid-containing product, are far little understood. In the present study, we assessed the impact of a heparinoid-containing product, Hirudoid

Indexed as

Administration, CutaneousAnimalsDrug Evaluation, PreclinicalEpidermisHeparinoidsHomeostasisMice, Inbred C57BLPermeabilityHeparinoidsHirudoidbarrier functiondifferentiationheparinoidstratum corneum hydration

Identifiers

PMID31168829
PMCPMC6663615

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.