Evidence map›Paper›PMID 31168787›Full record

ArticleJournal of clinical ultrasound : JCU2019

Lagrangian carotid strain imaging indices normalized to blood pressure for vulnerable plaque.

Tomy Varghese, Nirvedh H Meshram, Carol C Mitchell, Stephanie M Wilbrand, Bruce P Hermann, Robert J Dempsey

Open access · greenAbstract read
In one paragraph

Article in Journal of clinical ultrasound : JCU, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Tomy VargheseDepartment of Medical Physics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.ORCID https://orcid.org/0000-0003-3299-9130
Nirvedh H MeshramDepartment of Medical Physics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
Carol C MitchellDepartment of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
Stephanie M WilbrandDepartment of Neurological Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
Bruce P HermannDepartment of Neurology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
Robert J DempseyDepartment of Neurological Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
University of Wisconsin–Madison · US

Funding

Real-time Ultrasonic Monitoring of Tumor AblationR01CA112192 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI VARGHESE, TOMY · 2007 to 2017
$2.6M
Structural Stability of Carotid Plaque and SymptomatologyR01NS064034 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI DEMPSEY, ROBERT J · 2010 to 2014
$1.5M
NCI NIH HHS R01 CA112192NIH HHS 2R01 CA112192NINDS NIH HHS R01 NS064034NVIDIA Corporation Tesla K40 GPUOffice of the Vice Chancellor for ResearchUniversity of Wisconsin-MadisonWisconsin Alumni Research Foundation
6 · The paper itself

Abstract

objectiveUltrasound Lagrangian carotid strain imaging (LCSI) utilizes physiological deformation caused by arterial pressure variations to generate strain tensor maps of the vessel walls and plaques. LCSI has been criticized for the lack of normalization of magnitude-based strain indices to physiological stimuli, namely blood pressure. We evaluated the impact of normalization of magnitude-based strain indices to blood pressure measured immediately after the acquisition of radiofrequency (RF) data loops for LCSI. MATERIALS AND

methodsA complete clinical ultrasound examination along with RF data loops for LCSI was performed on 50 patients (30 males and 20 females) who presented with >60% carotid stenosis and were scheduled for carotid endarterectomy. Cognition was assessed using the 60-minute neuropsychological test protocol.

resultsFor axial strains correlation of maximum accumulated strain indices (MASI), cognition scores were -0.46 for non-normalized and -0.45, -0.49, -0.37, and -0.48 for systolic, diastolic, pulse pressure, and mean arterial pressure normalized data, respectively. The corresponding area under the curve (AUC) values for classifiers designed using maximum likelihood estimation of a binormal distribution with a median-split of the executive function cognition scores were 0.73, 0.70, 0.71, 0.70, and 0.71, respectively.

conclusionsNo significant differences in the AUC estimates were obtained between normalized and non-normalized magnitude-based strain indices.

Indexed as

AgedBlood PressureCarotid ArteriesCarotid StenosisFemaleHumansMalePlaque, AtheroscleroticUltrasonographycarotid strain imagingcognitionelastographystrain indicesultrasonography

Identifiers

PMID31168787
PMCPMC6760247
OpenAlexW2972996896

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.