Evidence map›Paper›PMID 31168785›Full record

ArticleBritish journal of haematology2019

Rapid decline in estimated glomerular filtration rate is common in adults with sickle cell disease and associated with increased mortality.

Vimal K Derebail, Qingning Zhou, Emily J Ciccone, Jianwen Cai, Kenneth I Ataga

Abstract read
In one paragraph

Article in British journal of haematology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Vimal K DerebailDivision of Nephrology and Hypertension, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0002-7662-7497
Qingning ZhouDepartment of Mathematics and Statistics, University of North Carolina at Charlotte, Charlotte, NC, USA.
Emily J CicconeDivision of Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Jianwen CaiDepartment of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Kenneth I AtagaCenter for Sickle Cell Disease, University of Tennessee Health Science Center, Memphis, TN, USA.ORCID 0000-0002-4501-9982

Funding

Re-Entry Supplement: Investigation of Oral Microbial Enzymes for the Detection and Treatment of Periodontal DiseaseUL1TR002489 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BUSE, JOHN BERNARD, SHAHEEN, NICHOLAS J · 2018 to 2022
$48.6M
North Carolina Translational & Clinical Sciences Institute (NC TraCS)UL1TR001111 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BUSE, JOHN BERNARD, CAREY, TIMOTHY S · 2013 to 2017
$43.9M
Epigenetic Regulation of T cell differentiationZIAHL006030 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI ZHAO, KEJI · 2009 to 2025
$15.3M
Endothelial Dysfunction in the Pathogenesis of Sickle Cell NephropathyR01HL111659 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ARCHER, DAVID R, ATAGA, KENNETH I · 2012 to 2016
$2.3M
THE ASSOCIATION OF BIOMARKERS OF ENDOTHELIAL FUNCTION WITH PROSPECTIVE CHANGES IN KIDNEY FUNCTION IN SICKLE CELL ANEMIAR01FD006030 · FDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ATAGA, KENNETH I · 2017 to 2021
$2.0M
FDA HHS R01 FD006030NCATS NIH HHS UL1 TR001111NCATS NIH HHS UL1 TR002489NHLBI NIH HHS R01 HL111659
6 · The paper itself

Abstract

We evaluated the prevalence of rapid decline in kidney function, its potential risk factors and influence upon mortality in sickle cell disease (SCD) in a retrospective single-center study. Rapid decline of kidney function was defined as estimated glomerular filtration rate (eGFR) loss of >3·0 ml/min/1·73 m

Indexed as

Anemia, Sickle CellAngiotensin-Converting Enzyme InhibitorsAngiotensin Receptor AntagonistsGlomerular Filtration RateModels, BiologicalAdultFemaleFollow-Up StudiesHumansMaleRetrospective StudiesAngiotensin-Converting Enzyme InhibitorsAngiotensin Receptor Antagonistschronic kidney diseaseglomerular filtrationkidney functionsickle cell disease

Identifiers

PMID31168785
PMCPMC6731158

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.