Evidence map›Paper›PMID 31168777›Full record

ArticleJournal of gastrointestinal cancer2020

Insulin Resistance and Colorectal Cancer Risk: the Role of Elevated Plasma Resistin Levels.

Hamid Farahani, Touraj Mahmoudi, Asadollah Asadi, Hossein Nobakht, Reza Dabiri, Amir Hamta

Abstract read
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In one paragraph

Article in Journal of gastrointestinal cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 3 pooled it
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 3 syntheses or guidelines pooled it, 69 citations in OpenAlex.

  1. Pooled it
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  3. Association between smoking and colorectal cancer in Eastern Mediterranean Regional Office (EMRO): A systematic review and meta-analysis.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Hamid FarahaniDepartment of Physiology, School of Medicine, Qom University of Medical Sciences, Alqadir Boulevard, 3736175513, Qom, Iran. farahani42@gmail.com.
Touraj MahmoudiGastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Asadollah AsadiDepartment of Biology, Faculty of Science, University of Mohaghegh Ardabili, Ardabil, Iran.
Hossein NobakhtInternal Medicine Department, Semnan University of Medical Sciences, Semnan, Iran.
Reza DabiriInternal Medicine Department, Semnan University of Medical Sciences, Semnan, Iran.
Amir HamtaDepartment of Social Medicine, School of Medicine, Qom University of Medical Sciences, Qom, Iran.
Qom University of Medical Science and Health Services · IRSemnan University of Medical Sciences · IRShahid Beheshti University of Medical Sciences · IRUniversity of Mohaghegh Ardabili · IR

Funding

Qom University of Medical Sciences 94536
6 · The paper itself

Abstract

purposeGiven the important role of resistin in insulin resistance (IR) and obesity, as well as the associations between both IR and obesity and increased risk of colorectal cancer (CRC), we investigated whether plasma resistin levels were associated with CRC risk. Furthermore, the possible correlations between resistin and insulin, IR, and obesity in patients with CRC and controls were explored.

methodsThis study was conducted as a case-control study and 170 subjects, including 88 controls and 82 cases with CRC, were enrolled and their plasma levels of glucoe, insulin, and resistin were measured using glucose oxidase or ELISA methods. Moreover, IR was calculated according to HOMA-IR index.

resultsThe cases with CRC had a higher HOMA-IR than the controls (1.8 ± 0.4 versus 1.4 ± 0.3, P < 0.001). Additionally, after the stratification of the cases with CRC by tumor site, higher levels of resistin and insulin, and a higher HOMA-IR in the cases with rectal cancer than in the controls were observed (resistin 5.9 ± 1.2 versus 5.4 ± 1.3, P = 0.043; insulin 5.9 ± 1.2 versus 5.4 ± 1.3, P = 0.039; HOMA- IR 1.9 ± 0.4 versus 1.3 ± 0.3, P < 0.001). Furthermore, resistin was positively correlated with insulin in the controls (r = 0.737, P < 0.001), the cases with CRC (r = 0.881, P < 0.001), the cases with colon cancer (r = 0.811, P < 0.001), and the cases with rectal cancer (r = 0.990, P < 0.001). All these differences remained significant after adjustment for confounding factors.

conclusionsThe findings of the present study reinforce the hypothesis that higher plasma levels of resistin in connection with insulin resistance play a role in susceptibility to colorectal, notably rectal, cancer. Nevertheless, further studies with bigger sample sizes are required to validate these findings.

Indexed as

AdultAgedAged, 80 and overCase-Control StudiesColorectal NeoplasmsFemaleHumansInsulin ResistanceMaleMiddle AgedResistinRisk FactorsResistinColorectal cancerInsulin resistanceIRObesityPlasmaResistin

Identifiers

PMID31168777
OpenAlexW2955399628

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.