ArticleApplied microbiology and biotechnology2019
Effect of ethanol supplementation on the transcriptional landscape of bionanocellulose producer Komagataeibacter xylinus E25.
Article in Applied microbiology and biotechnology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26 citing papers in PubMed, 63 citations in OpenAlex.
- Kombucha-Derived Bacterial Cellulose for Active and Biodegradable Food Packaging: Production, Modification, Performance, and Current Challenges.Molecules (Basel, Switzerland) · 2026Review
- Bacterial nanocellulose: biosynthesis, structural properties and vascular tissue engineering applications.Journal of materials science. Materials in medicine · 2026Review
- Comparative Analysis of Lineage Structure, Cellulose Locus Context, and Mobilome Diversity Across CompleteMicroorganisms · 2026Article
- The Effect ofInternational journal of molecular sciences · 2025Article
- Bacterial cellulose production under agitated culture conditions using tobacco waste extract by a strain of Komagataeibacter sp. isolated from rotten mango.Biotechnology letters · 2025Article
- Transcriptional reprogramming of Novacetimonas hansenii SI1 during growth on glycerol.Applied microbiology and biotechnology · 2025Article
- Bioconversion of Date Waste into Bacterial Nanocellulose by a New IsolateFoods (Basel, Switzerland) · 2025Article
- Utilization of gamma irradiated emulsified frying oil wastes as a carbon source for sustainable and economical production of bacterial cellulose membrane.BMC microbiology · 2025Article
- Bacterial Cellulose for Scalable and Sustainable Bio-Gels in the Circular Economy.Gels (Basel, Switzerland) · 2025Review
- Machine Learning and Multi-Omics Integration to Reveal Biomarkers and Microbial Community Assembly Differences in Abnormal Stacking Fermentation of Sauce-FlavorFoods (Basel, Switzerland) · 2025Article
- How carbon sources drive cellulose synthesis in two Komagataeibacter xylinus strains.Scientific reports · 2024Article
- Metabolomic kinetics investigation ofHeliyon · 2024Article
- Enhanced bacterial cellulose production in Komagataeibacter sucrofermentans: impact of different PQQ-dependent dehydrogenase knockouts and ethanol supplementation.Biotechnology for biofuels and bioproducts · 2024Article
- Characterization of the Putative Acylated Cellulose Synthase Operon inInternational journal of molecular sciences · 2022Article
- The Roles of the Various Cellulose Biosynthesis Operons inApplied and environmental microbiology · 2022Article
- Comparative Analysis of Bacterial Cellulose Membranes Synthesized by ChosenInternational journal of molecular sciences · 2022Article
- Highly Stretchable Bacterial Cellulose Produced byPolymers · 2021Article
- Transcriptome Analysis ofPolish journal of microbiology · 2021Article
- Bacterial cellulose spheroids as building blocks for 3D and patterned living materials and for regeneration.Nature communications · 2021Article
- From Residues to Added-Value Bacterial Biopolymers as Nanomaterials for Biomedical Applications.Nanomaterials (Basel, Switzerland) · 2021Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ethanol exerts a strong positive effect on the cellulose yields from the widely exploited microbial producers of the Komagataeibacter genus. Ethanol is postulated to provide an alternative energy source, enabling effective use of glucose for cellulose biosynthesis rather than for energy acquisition. In this paper, we investigate the effect of ethanol supplementation on the global gene expression profile of Komagataeibacter xylinus E25 using RNA sequencing technology (RNA-seq). We demonstrate that when ethanol is present in the culture medium, glucose metabolism is directed towards cellulose production due to the induction of genes related to UDP-glucose formation and the repression of genes involved in glycolysis and acetan biosynthesis. Transcriptional changes in the pathways of cellulose biosynthesis and c-di-GMP metabolism are also described. The transcript level profiles suggest that Schramm-Hestrin medium supplemented with ethanol promotes bacterial growth by inducing protein biosynthesis and iron uptake. We observed downregulation of genes encoding transposases of the IS110 family which may provide one line of evidence explaining the positive effect of ethanol supplementation on the genotypic stability of K. xylinus E25. The results of this study increase knowledge and understanding of the regulatory effects imposed by ethanol on cellulose biosynthesis, providing new opportunities for directed strain improvement, scaled-up bionanocellulose production, and wider industrial exploitation of the Komagataeibacter species as bacterial cellulose producers.
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