Observational studyClinical research in cardiology : official journal of the German Cardiac Society2020
Choroidal thickness is associated with cardiovascular risk factors and cardiac health: the Gutenberg Health Study.
Observational study in Clinical research in cardiology : official journal of the German Cardiac Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
16 citing papers in PubMed, 26 citations in OpenAlex.
- Ocular microvascular alterations in patients with heart failure with preserved ejection fraction.Japanese journal of ophthalmology · 2026Observational
- A deep-learning system for the assessment of coronary heart disease risk via scleral photographs.Scientific reports · 2025Article
- Retinal and Choroidal Alterations in Heart Failure: A Systematic Review and Meta-analysis of OCT and OCT-A Findings with Emphasis on HFrEF.Ophthalmology and therapy · 2025Review
- Retinal Imaging as a Window into Cardiovascular Health: Towards Harnessing Retinal Analytics for Precision Cardiovascular Medicine.Journal of cardiovascular development and disease · 2025Review
- Assessment of macular choroidal and retinal thickness: a cohort study in Tibetan healthy children.Scientific reports · 2024Article
- Comparison of choroidal thickness and choroidal vascular index in normotensive dippers and nondippers.Revista da Associacao Medica Brasileira (1992) · 2024Article
- Retinal Findings and Cardiovascular Risk: Prognostic Conditions, Novel Biomarkers, and Emerging Image Analysis Techniques.Journal of personalized medicine · 2023Review
- Evaluation of Arterial Stiffness and Subfoveal Choroidal Thickness in Patients with Coronary Slow Flow.Acta Cardiologica Sinica · 2023Article
- Choroidal thickness changes in children with chronic heart failure due to dilated cardiomyopathy.International ophthalmology · 2021Article
- Aortic pulsatility drives microvascular organ damage in essential hypertension: New evidence from choroidal thickness assessment.Journal of clinical hypertension (Greenwich, Conn.) · 2021Article
- Evaluation of Choroidal Thickness Using Optical Coherent Tomography: A Review.Frontiers in medicine · 2021Review
- Observational
- Relationship Between Renal Function and Choroidal Thickness in Type 2 Diabetic Patients Detected by Swept-Source Optical Coherence Tomography.Translational vision science & technology · 2020Article
- Impact of Carotid Endarterectomy on Choroidal Thickness and Volume in Enhanced Depth Optical Coherence Tomography Imaging.Journal of ophthalmology · 2020Article
- Assessment of the Effect of Vitiligo on Subfoveal Choroidal Thickness Using Spectral-Domain Optical Coherence Tomography.Clinical ophthalmology (Auckland, N.Z.) · 2020Article
- Microvascular contributions to age-related macular degeneration (AMD): from mechanisms of choriocapillaris aging to novel interventions.GeroScience · 2019Review
Corrections and comments
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Authors and funding
15 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChoroidal thickness is associated with several cardiovascular parameters in case-control studies including patients with manifest disease. So far, it was unclear whether underlying cardiovascular risk factors or the continuum of heart failure may lead to alterations of the choroid. Therefore, our hypothesis was to test in a population-based study, whether choroidal thickness is associated with cardiovascular risk factors and heart disease.
methodsA population-based cross-sectional study was carried out in Germany. A comprehensive medical examination including assessment of cardiovascular risk factors, echocardiography and ophthalmological examinations with spectral-domain optical coherence tomography of the choroid was performed. Subfoveal choroidal thickness as well as left ventricular ejection fraction (LVEF) and a surrogate marker for left ventricular end-diastolic pressure (E/e') were measured. Linear regression analyses were carried out to determine the relationship between subfoveal choroidal thickness and age, sex, body mass index, systolic blood pressure, dyslipidemia, HbA1c level, hematocrit, estimated glomerular filtration rate (eGFR), LVEF, E/e' and left ventricular mass index adjusted for ocular parameters.
results1.742 subjects (48% females) with a mean age 59.3 ± 10.6 years were included in this study. Mean subfoveal thickness was 252 ± 77 µm (right eyes) and 255 ± 77 µm (left eyes). Unadjusted linear regression analysis revealed that subfoveal choroidal thickness is associated with sex, age, systolic blood pressure, hematocrit, eGFR, left ventricular end-diastolic pressure, left ventricular mass index (all p < 0.001) and dyslipidemia (p = 0.009). Adjusted linear regression only revealed age as associated parameter (p < 0.001).
conclusionsWe did find evidence for an association between subfoveal choroidal thickness and cardiovascular risk factors which was mediated by aging.
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