Evidence map›Paper›PMID 31168608›Full record

ArticleEuropace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology2019

Long-term single-centre large volume experience with transseptal endocardial left ventricular lead implantation.

László Gellér, Zoltán Salló, Levente Molnár, Tamás Tahin, Emin Evren Özcan, Valentina Kutyifa, István Osztheimer, Szabolcs Szilágyi, Nándor Szegedi, Pál Ábrahám and 7 more

Abstract read
In one paragraph

Article in Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
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  9. Review
  10. Determinants of Response to Cardiac Resynchronization Therapy.The Journal of innovations in cardiac rhythm management · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

László GellérDepartment of Cardiology, The Heart and Vascular Center of Semmelweis University, Városmajor street 68, Budapest H, Hungary.
Zoltán SallóDepartment of Cardiology, The Heart and Vascular Center of Semmelweis University, Városmajor street 68, Budapest H, Hungary.
Levente MolnárDepartment of Cardiology, The Heart and Vascular Center of Semmelweis University, Városmajor street 68, Budapest H, Hungary.
Tamás TahinDepartment of Cardiology, St. Rafael Hospital, Zrínyi street 1, Zalaegerszeg H, Hungary.
Emin Evren ÖzcanDepartment of Cardiology, Faculty of Medicine, Dokuz Eylül University, Kültür Mahallesi, Cumhuriyet Blv No: 144, İzmir, Turkey.
Valentina KutyifaDepartment of Cardiology, The Heart and Vascular Center of Semmelweis University, Városmajor street 68, Budapest H, Hungary.
István OsztheimerDepartment of Cardiology, The Heart and Vascular Center of Semmelweis University, Városmajor street 68, Budapest H, Hungary.
Szabolcs SzilágyiDepartment of Cardiology, The Heart and Vascular Center of Semmelweis University, Városmajor street 68, Budapest H, Hungary.
Nándor SzegediDepartment of Cardiology, The Heart and Vascular Center of Semmelweis University, Városmajor street 68, Budapest H, Hungary.
Pál ÁbrahámDepartment of Cardiology, The Heart and Vascular Center of Semmelweis University, Városmajor street 68, Budapest H, Hungary.
Astrid AporDepartment of Cardiology, The Heart and Vascular Center of Semmelweis University, Városmajor street 68, Budapest H, Hungary.
Klaudia Vivien NagyDepartment of Cardiology, The Heart and Vascular Center of Semmelweis University, Városmajor street 68, Budapest H, Hungary.
Annamária KosztinDepartment of Cardiology, The Heart and Vascular Center of Semmelweis University, Városmajor street 68, Budapest H, Hungary.
Dávid BeckerDepartment of Cardiology, The Heart and Vascular Center of Semmelweis University, Városmajor street 68, Budapest H, Hungary.
Szilvia HerczegDepartment of Cardiology, The Heart and Vascular Center of Semmelweis University, Városmajor street 68, Budapest H, Hungary.
Endre ZimaDepartment of Cardiology, The Heart and Vascular Center of Semmelweis University, Városmajor street 68, Budapest H, Hungary.
Béla MerkelyDepartment of Cardiology, The Heart and Vascular Center of Semmelweis University, Városmajor street 68, Budapest H, Hungary.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsThe aim of our study was to investigate the long-term efficacy and safety of transseptal endocardial left ventricular lead implantation (TELVLI). METHODS AND

resultsTransseptal endocardial left ventricular lead implantation was performed in 54 patients (44 men, median age 69, New York Heart Association III-IV stage) between 2007 and 2017 in a single centre. In 36 cases, the transseptal puncture (TP) was performed via the femoral vein, and in 18 cases, the TP and also the left ventricular (LV) lead placement were performed via the subclavian vein. An electrophysiological deflectable catheter was used to reach the LV wall through the dilated TP hole. The LV lead implantation was successful in all patients. A total of 54 patients were followed up for a median of 29 months [interquartile range (IQR) 8-40 months], the maximum follow-up time was 94 months. Significant improvement in the LV ejection fraction was observed at the 3-month visit, from the median of 27% (IQR 25-34%) to 33% (IQR 32-44%), P < 0.05. Early lead dislocation was observed in three cases (5%), reposition was performed using the original puncture site in all. The patients were maintained on anticoagulation therapy with a target international normalized ratio between 2.5 and 3.5. Four thromboembolic events were noticed during follow-up. A total of 27 patients died, with a median survival of 15 months (IQR 6-40).

conclusionThe TELVLI is an effective approach for cardiac resynchronization therapy (CRT) however it is associated with a substantial thromboembolic risk (7%).

Indexed as

Cardiac Resynchronization TherapyProsthesis ImplantationThromboembolismAgedCardiac Resynchronization Therapy DevicesElectrodes, ImplantedEquipment FailureFemaleHeart FailureHeart SeptumHeart VentriclesHumansHungaryMaleOutcome and Process Assessment, Health CarePostoperative ComplicationsCardiac resynchronization therapyEndocardialHeart failureLeadTransseptal

Identifiers

PMID31168608
PMCPMC6680368

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.