ArticleEpilepsia open2019
Enhanced responses to somatostatin interneuron activation in developmentally malformed cortex.
Article in Epilepsia open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 4 citations in OpenAlex.
- Cell-specific switch for epileptiform activity: critical role of interneurons in the mouse subicular network.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Enhanced responses to somatostatin interneuron activation in developmentally malformed cortex.Epilepsia open · 2019Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Intractable epilepsy is commonly associated with developmental cortical malformations. Using the rodent freeze lesion model, we have sought the underlying circuit abnormalities contributing to the epileptiform activity that occurs in association with the structural pathology of four-layered microgyria. We showed previously that within the epileptogenic paramicrogyral region (PMR) surrounding the malformation, non-fast-spiking neurons commonly containing somatostatin (SSt) exhibit alterations, including having a greater maximum firing rate. Here we examined the output of SSt interneurons with optogenetics, using SSt-Cre mice mated to mice with floxed channelrhodopsin-2. Voltage clamp recordings from layer V pyramidal neurons in ex vivo slices had significantly enhanced SSt-evoked inhibitory postsynaptic currents in PMR cortex compared to control. In addition, under conditions of low-Mg
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