ArticleIranian journal of basic medical sciences2019
Baicalein, a flavonoid, causes prolonged estrus and suppressed fertility output upon prenatal exposure in female mice.
Article in Iranian journal of basic medical sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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Who cites it
4 citing papers in PubMed, 10 citations in OpenAlex.
- Urate-lowering effect of delphinidin-3-glucoside in red kidney beans via binding to the FAD site of the XO enzyme.Journal of advanced research · 2026Article
- Polyphenolic metabolites inFrontiers in pharmacology · 2025Review
- Effect of Silymarin Supplementation on Physical Performance, Muscle and Myocardium Histological Changes, Bodyweight, and Food Consumption in Rats Subjected to Regular Exercise Training.International journal of molecular sciences · 2020Article
- Contribution of potassium channels, beta2-adrenergic and histamine H1 receptors in the relaxant effect of baicalein on rat tracheal smooth muscle.Iranian journal of basic medical sciences · 2019Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesBaicalein (BC), a phytoestrogen of the flavonoid family shows beneficiary and adverse effects. Effect of BC on reproduction is still not understood. Reproductive toxic effects on female mice were tested in this study. MATERIALS AND
methodsInseminated Wistar mice were divided into four groups and administered IP with 30, 60, and 90 mg/Kg body weight of BC on gestation days 11, 13, 15, and 17, and controls treated with DMSO. They were allowed to deliver pups and offspring were separated gender-wise on day 21. The stages of the estrus cycle and its lengthlengths of three successive cycles were measured from day 38 of young females. The mature female offspring of at 60 days age havewere cohabited with control males and the female reproductive endpoints and body weights of dams were measured.
resultsThe BC exposure increased the length of the estrus cycle, especially the metestrus and diestrus phases were prolonged among other phases of the estrus cycle. Recorded significant reduction in the body weights (
conclusionPrenatal BC exposure prolonged the estrus cycle due to the augmented length of metestrus and diestrus phase, and is reportingreported for the first time. Female fertility output in mice is affected severely by prenatal BC exposure.
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