ArticleGreen chemistry : an international journal and green chemistry resource : GC2019
Bio-derived Production of Cinnamyl Alcohol via a Three Step Biocatalytic Cascade and Metabolic Engineering.
Article in Green chemistry : an international journal and green chemistry resource : GC, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Advances in integrating microbial metabolism with catalytic systems.Nature chemical biology · 2025Review
- Carboxylic acid reductase-dependent biosynthesis of eugenol and related allylphenols.Microbial cell factories · 2023Article
- In-depth Sequence-Function Characterization Reveals Multiple Pathways to Enhance Enzymatic Activity.ACS catalysis · 2022Article
- Chemoenzymatic one-pot reaction from carboxylic acid to nitrileCatalysis science & technology · 2022Article
- Metabolic engineering of Escherichia coli for de novo production of 3-phenylpropanol via retrobiosynthesis approach.Microbial cell factories · 2021Article
- RetroBioCat as a computer-aided synthesis planning tool for biocatalytic reactions and cascades.Nature catalysis · 2021Article
- The power of electrified nanoconfinement for energising, controlling and observing long enzyme cascades.Nature communications · 2021Article
- Efficient biosynthesis of cinnamyl alcohol by engineered Escherichia coli overexpressing carboxylic acid reductase in a biphasic system.Microbial cell factories · 2020Article
- Discovery, Characterisation, Engineering and Applications of Ene Reductases for Industrial Biocatalysis.ACS catalysis · 2019Article
- Extending Designed Linear Biocatalytic Cascades for Organic Synthesis.ChemCatChem · 2019Review
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Authors and funding
5 authors.
Funding
Abstract
The construction of biocatalytic cascades for the production of chemical precursors is fast becoming one of the most efficient approaches to multi-step synthesis in modern chemistry. However, despite the use of low solvent systems and renewably-resourced catalysts in reported examples, many cascades are still dependent on petrochemical starting materials, which as of yet cannot be accessed in a sustainable fashion. Herein we report the production of the versatile chemical building block cinnamyl alcohol from the primary metabolite and fermentation product L-phenylalanine. Through the combination of three biocatalyst classes (phenylalanine ammonia lyase, carboxylic acid reductase and alcohol dehydrogenase) the target compound could be reached in high purity, demonstrable at 100 mg scale achieving 53 % yield using ambient temperature and pressure in aqueous solution. This system represents a synthetic strategy in which all components present at time zero are biogenic and thus minimising damage to the environment. Further we extend this biocatalytic cascade by its inclusion in a L-phenylalanine overproducing strain of
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.