ArticleNature2019
Group 3 innate lymphoid cells mediate early protective immunity against tuberculosis.
Erratum issuedOpen access · greenAbstract read
In one paragraph
Article in Nature, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 144 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
144citing papers in PubMed, 1 pooled it
11.0field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
144 citing papers in PubMed, 1 synthesis or guideline pooled it, 205 citations in OpenAlex.
- Safety of Interleukin Inhibitors in Psoriatic Patients with Latent Tuberculosis Infection Without Chemoprophylaxis: A Systematic Review.Acta dermato-venereologica · 2025Pooled it
- Targeting the GPR183/EBI2‒oxysterol axis in tuberculosis: Immunometabolic regulation and prospects for host-directed therapy.Clinical and translational medicine · 2026Review
- CXCL13⁺ CD4⁺ T cells are associated with B-cell recruitment and lesion progression in cerebral cavernous malformations.Journal of neuroinflammation · 2026Article
- Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection.FEBS open bio · 2026Review
- Context-specific roles for IL-17 in tuberculosis.PLoS pathogens · 2026Review
- Rare variable M. tuberculosis antigens induce predominant Th17 responses in human infection.JCI insight · 2026Article
- Single-cell and spatial profiling highlights TB-induced myofibroblasts as drivers of lung pathology.The Journal of experimental medicine · 2026Article
- Article
- The context-dependent role of group 2 innate lymphoid cells in lung diseases.Acta biochimica et biophysica Sinica · 2026Review
- Immunotherapy for tuberculosis: emerging modalities, cross-disciplinary innovations, and roadmaps for drug-resistant disease.Frontiers in immunology · 2026Review
- Defective IL-17 production is associated with reduced IL-1β levels in response toFrontiers in immunology · 2026Article
- T cell-macrophage interactions in tuberculosis: What we've got here is failure to communicate.Journal of internal medicine · 2026Review
- From microbiome to outcome: the cascading effects of combining acid suppressants with anti-tuberculosis therapy.Frontiers in medicine · 2026Review
- B cells and iBALT in TB immunity & pathogenesis.Frontiers in immunology · 2026Review
- Trained ILCs confer adaptive immunity-independent protection against influenza.Journal of virology · 2025Article
- Mast cells promote pathology and susceptibility in tuberculosis.bioRxiv : the preprint server for biology · 2025Article
- Characterization of a mouse model of osteoarticular infection using clinical isolates ofJBMR plus · 2025Article
- An alveolus lung-on-a-chip model of Mycobacterium fortuitum lung infection.Disease models & mechanisms · 2025Article
- BCG Vaccine-Induced Innate and Adaptive Pulmonary Immunity Correlating with Protective Efficacy AgainstVaccines · 2025Article
- Dendritic Cells and Their Crucial Role in Modulating Innate Lymphoid Cells for Treating and Preventing Infectious Diseases.Pathogens (Basel, Switzerland) · 2025Review
84 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
36 authors at 10 institutions in 6 countries.
Amanda ArdainAfrica Health Research Institute, Durban, South Africa.
Racquel Domingo-GonzalezDepartment of Molecular Microbiology, Washington University School of Medicine, St Louis, MO, USA.
Shibali DasDepartment of Molecular Microbiology, Washington University School of Medicine, St Louis, MO, USA.
Samuel W KazerInstitute for Medical Engineering and Science, Department of Chemistry, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
Nicole C HowardDepartment of Molecular Microbiology, Washington University School of Medicine, St Louis, MO, USA.
Alveera SinghAfrica Health Research Institute, Durban, South Africa.
Mushtaq AhmedDepartment of Molecular Microbiology, Washington University School of Medicine, St Louis, MO, USA.
Shepherd NhamoyebondeAfrica Health Research Institute, Durban, South Africa.
Javier Rangel-MorenoDivision of Allergy, Immmunology and Rheumatology, Department of Medicine, University of Rochester Medical Center, Rochester, NY, USA.
Paul OgongoAfrica Health Research Institute, Durban, South Africa.
Lan LuDepartment of Molecular Microbiology, Washington University School of Medicine, St Louis, MO, USA.
Duran RamsuranSchool of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa.
Maria de la Luz Garcia-HernandezDivision of Allergy, Immmunology and Rheumatology, Department of Medicine, University of Rochester Medical Center, Rochester, NY, USA.
Tyler K UllandDivision of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA.
Matthew DarbyIDM, University of Cape Town, Cape Town, South Africa.
Eugene ParkDivision of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA.
Farina KarimAfrica Health Research Institute, Durban, South Africa.
Laura MelocchiDivision of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA.
Rajhmun MadanseinDepartment of Cardiothoracic Surgery, Nelson Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.
Kaylesh Jay DullabhDepartment of Cardiothoracic Surgery, Nelson Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.
Micah DunlapDepartment of Molecular Microbiology, Washington University School of Medicine, St Louis, MO, USA.
Nancy Marin-AgudeloDepartment of Molecular Microbiology, Washington University School of Medicine, St Louis, MO, USA.
Takashi EbiharaDivision of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA.
Thumbi Ndung'uAfrica Health Research Institute, Durban, South Africa.
Deepak KaushalTulane National Primate Research Center, Covington, LA, USA.
Alexander S PymAfrica Health Research Institute, Durban, South Africa.
Jay K KollsTulane University Health Sciences, New Orleans, LA, USA.
Adrie SteynAfrica Health Research Institute, Durban, South Africa.
Joaquín ZúñigaInstituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Mexico City, Mexico.
William HorsnellIDM, University of Cape Town, Cape Town, South Africa.
Wayne M YokoyamaDivision of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA.
Alex K ShalekInstitute for Medical Engineering and Science, Department of Chemistry, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
Henrik N KløverprisAfrica Health Research Institute, Durban, South Africa.
Marco ColonnaDivision of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA.
Alasdair LeslieAfrica Health Research Institute, Durban, South Africa. al.leslie@ahri.org.
Shabaana A KhaderDepartment of Molecular Microbiology, Washington University School of Medicine, St Louis, MO, USA. sakhader@wustl.edu.
Washington University in St. Louis · USUniversity of KwaZulu-Natal · ZAAfrica Health Research Institute · ZAHoward Hughes Medical Institute · USMassachusetts Institute of Technology · USTulane University · USUniversity of Cape Town · ZAUniversity of Rochester Medical Center · USInstitute of Primate Research · KEInstituto Nacional de Enfermedades Respiratorias · MX
Funding
PRINCIPLES IN PULMONARY RESEARCHT32HL007317 · NHLBI · WASHINGTON UNIVERSITY · PI Steven Brody, Michael J Holtzman · 1985 to 2026
$16.1MUniversiity of Rochester Center for Medical Countermeasures against RadiationU19AI091036 · NIAID · UNIVERSITY OF ROCHESTER · PI CHEN, YUHCHYAU · 2010 to 2014
$15.6MTRAINING PROGRAM IN IMMUNOLOGY AND IMMUNOGENETICST32AI007163 · NIAID · WASHINGTON UNIVERSITY · PI Kenneth M Murphy, Kodi S Ravichandran · 1985 to 2026
$14.8MInfectious Diseases/Basic Microbial Pathogenic MechanismsT32AI007172 · NIAID · WASHINGTON UNIVERSITY · PI Daniel E. Goldberg, JENNIFER A PHILIPS · 1985 to 2026
$13.0MROLE OF INDUCIBLE BRONCHUS ASSOCIATED LYMPHOID TISSUE IN LATENT TUBERCULOSISR01AI111914 · NIAID · WASHINGTON UNIVERSITY · PI KAUSHAL, DEEPAK, KHADER, SHABAANA A. · 2015 to 2025
$11.1MTraining in CD4 T-cell Lung ImmunityR35HL139930 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI KOLLS, JAY K · 2018 to 2024
$6.3MROLE OF IL-17 IN PROTECTIVE VACCINE-INDUCED IMMUNE RESPONSES AGAINST TUBERCULOSISR01HL105427 · NHLBI · WASHINGTON UNIVERSITY · PI KHADER, SHABAANA A. · 2011 to 2025
$5.9MThe Role of Group 3 Innate Lymphoid cells (ILC3) in TuberculosisR01AI134236 · NIAID · WASHINGTON UNIVERSITY · PI COLONNA, MARCO, KHADER, SHABAANA A. · 2017 to 2021
$4.4MCOMMON IMMUNE CORRELATES OF RISK OF TB DISEASE IN ANIMAL MODELS AND HUMANSR01AI123780 · NIAID · WASHINGTON UNIVERSITY · PI KAUSHAL, DEEPAK, KHADER, SHABAANA A. · 2016 to 2019
$2.9MAn integrated multiplexed genomic assay for low input clinical samples1U24AI118672 · NIAID · BROAD INSTITUTE, INC. · PI SHALEK, ALEX K · 2015 to 2019
$2.0MNHLBI NIH HHS R01 HL105427NHLBI NIH HHS R35 HL139930NHLBI NIH HHS T32 HL007317NIAID NIH HHS R01 AI111914NIAID NIH HHS R01 AI123780NIAID NIH HHS R01 AI134236NIAID NIH HHS T32 AI007163NIAID NIH HHS T32 AI007172NIAID NIH HHS U19 AI091036NIAID NIH HHS U24 AI118672Wellcome Trust 210662/Z/18/Z
Abstract
Tuberculosis is the leading cause of death by an infectious disease worldwide
Indexed as
AnimalsChemokine CXCL13FemaleGranulomaHumansImmunity, InnateInterleukin-17Interleukin-22InterleukinsLungLymphocytesMacrophages, AlveolarMaleMiceMycobacterium tuberculosisReceptors, CXCR5Chemokine CXCL13CXCL13 protein, humanCxcl13 protein, mouseCXCR5 protein, humanInterleukin-17Interleukin-22InterleukinsReceptors, CXCR5
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.