Evidence map›Paper›PMID 31167948›Full record

ArticlemSphere2019

Vitamin A Metabolism by Dendritic Cells Triggers an Antimicrobial Response against Mycobacterium tuberculosis.

Elliot W Kim, Avelino De Leon, Zhichun Jiang, Roxana A Radu, Adrian R Martineau, Edward D Chan, Xiyuan Bai, Wen-Lin Su, Dennis J Montoya, Robert L Modlin and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mSphere, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 35 citations in OpenAlex.

  1. The Impact of Vitamin A Deficiency on Tuberculosis Progression.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022
    Trial
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  11. AllCurrent research in immunology · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 3 countries.

Elliot W KimDepartment of Molecular Biology Institute, University of California, Los Angeles, Los Angeles, California, USA.
Avelino De LeonDivision of Dermatology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
Zhichun JiangStein Eye Institute and Department of Ophthalmology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
Roxana A RaduStein Eye Institute and Department of Ophthalmology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
Adrian R MartineauBarts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
Edward D ChanDepartment of Medicine and Academic Affairs, National Jewish Health, Denver, Colorado, USA.
Xiyuan BaiDepartment of Medicine and Academic Affairs, National Jewish Health, Denver, Colorado, USA.
Wen-Lin SuDivision of Pulmonary and Critical Care Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei, Taiwan.
Dennis J MontoyaDepartment of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, Los Angeles, California, USA.
Robert L ModlinDivision of Dermatology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
Philip T LiuDivision of Dermatology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA ptliu@mednet.ucla.edu.
University of California, Los Angeles · USNational Jewish Health · USQueen Mary University of London · GBTaipei Tzu Chi Hospital · TWUniversity of Colorado Denver · US

Funding

Virology CoreP30AI028697 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KITCHEN, SCOTT G · 1991 to 2018
$39.9M
Molecular Analysis of the Host Immune Response in LeprosyR01AI022553 · NIAID · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ROBERT L MODLIN · 1989 to 2026
$15.7M
TCR GAMMA/DELTA LYMPHOCYTES IN HUMAN SKIN LESIONSR01AR040312 · NIAMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MODLIN, ROBERT L · 1990 to 2025
$10.4M
Regenerative Musculoskeletal Medicine Training ProgramT32AR059033 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI John S Adams, Nicholas M. Bernthal · 2011 to 2026
$4.8M
IL-26 in host defense against infection by intracellular bacteria in skinR01AR073252 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MODLIN, ROBERT L · 2019 to 2023
$2.1M
Mechanism of retinoic acid receptor induced innate immune responsesK22AI085025 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LIU, PHILIP T. · 2010 to 2011
$267k
NIAID NIH HHS K22 AI085025NIAID NIH HHS P30 AI028697NIAID NIH HHS R01 AI022553NIAMS NIH HHS R01 AR040312NIAMS NIH HHS R01 AR073252NIAMS NIH HHS T32 AR059033
6 · The paper itself

Abstract

Epidemiological evidence correlates low serum vitamin A (retinol) levels with increased susceptibility to active tuberculosis (TB); however, retinol is biologically inactive and must be converted into its bioactive form, all-

Indexed as

3-Hydroxysteroid DehydrogenasesAdultAldehyde Dehydrogenase 1 FamilyCells, CulturedCulture Media, ConditionedDendritic CellsHumansLungMacrophagesMycobacterium tuberculosisRetinal DehydrogenaseTuberculosisVitamin A3-Hydroxysteroid DehydrogenasesAldehyde Dehydrogenase 1 FamilyALDH1A2 protein, humanCulture Media, ConditionedDHRS9 protein, humanRetinal DehydrogenaseVitamin Adendritic cellsMycobacterium tuberculosistranscellular metabolism

Identifiers

PMID31167948
PMCPMC6553556
OpenAlexW2948949729

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.