Evidence map›Paper›PMID 31167942›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

On the occurrence of cytochrome P450 in viruses.

David C Lamb, Alec H Follmer, Jared V Goldstone, David R Nelson, Andrew G Warrilow, Claire L Price, Marie Y True, Steven L Kelly, Thomas L Poulos, John J Stegeman

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 64 citations in OpenAlex.

  1. Article
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  5. Review
  6. Article
  7. Non-Canonical Cytochrome P450 Enzymes in Nature.bioRxiv : the preprint server for biology · 2024
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Evolution of Cytochrome P450 Enzymes and Their Redox Partners in Archaea.International journal of molecular sciences · 2023
    Article
  16. Spotlight on CYP4B1.International journal of molecular sciences · 2023
    Review
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

David C LambBiology Department, Woods Hole Oceanographic Institution, Woods Hole, MA 02543.
Alec H FollmerDepartment of Chemistry, University of California, Irvine, CA 92697-3900.
Jared V GoldstoneBiology Department, Woods Hole Oceanographic Institution, Woods Hole, MA 02543.
David R NelsonDepartment of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, TN 38163.
Andrew G WarrilowInstitute of Life Science, Swansea University Medical School, Swansea University, Swansea, SA2 8PP Wales, United Kingdom.
Claire L PriceInstitute of Life Science, Swansea University Medical School, Swansea University, Swansea, SA2 8PP Wales, United Kingdom.
Marie Y TrueDepartment of Pharmaceutical Sciences, University of California, Irvine, CA 92697-3900.
Steven L KellyInstitute of Life Science, Swansea University Medical School, Swansea University, Swansea, SA2 8PP Wales, United Kingdom.
Thomas L PoulosDepartment of Chemistry, University of California, Irvine, CA 92697-3900.
John J StegemanBiology Department, Woods Hole Oceanographic Institution, Woods Hole, MA 02543; jstegeman@whoi.edu.
Swansea University · GBUniversity of California, Irvine · USWoods Hole Oceanographic Institution · USUniversity of Tennessee Health Science Center · US

Funding

Training CoreP42ES007381 · NIEHS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI SHERR, DAVID H · 1995 to 2019
$46.1M
STRUCTURAL STUDIES ON NITRIC OXIDE SYNTHASER01GM057353 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI POULOS, THOMAS L · 1998 to 2018
$6.8M
Metalloenzyme structure, function, and as targets for neurodegeneration and bacterial pathogenesisR35GM131920 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI POULOS, THOMAS L · 2019 to 2023
$2.9M
Nomenclature of Human and Vertebrate GenesU41HG003345 · NHGRI · EUROPEAN MOLECULAR BIOLOGY LABORATORY · PI BIRNEY, EWAN, BRUFORD, ELSPETH · 2013 to 2017
$2.4M
WHCOHH: Harmful algal bloom dynamics and epigenetic mechanism of toxin actionP01ES021923 · NIEHS · WOODS HOLE OCEANOGRAPHIC INSTITUTION · PI ANDERSON, DONALD M · 2012 to 2016
$2.1M
NHGRI NIH HHS U41 HG003345NIEHS NIH HHS P01 ES021923NIEHS NIH HHS P42 ES007381NIGMS NIH HHS R01 GM057353NIGMS NIH HHS R35 GM131920
6 · The paper itself

Abstract

Genes encoding cytochrome P450 (CYP; P450) enzymes occur widely in the Archaea, Bacteria, and Eukarya, where they play important roles in metabolism of endogenous regulatory molecules and exogenous chemicals. We now report that genes for multiple and unique P450s occur commonly in giant viruses in the

Indexed as

Evolution, MolecularMultigene FamilyCytochrome P-450 Enzyme SystemVirusesCytochrome P-450 Enzyme Systemcytochrome P450domains of lifeevolutionredox partnervirus

Identifiers

PMID31167942
PMCPMC6589655
OpenAlexW2948922888

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.