ArticleScience translational medicine2019
Lymphocyte-driven regional immunopathology in pneumonitis caused by impaired central immune tolerance.
Abstract read
In one paragraph
Article in Science translational medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
6.5field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
53 citing papers in PubMed, 74 citations in OpenAlex.
- SARS-CoV-2 Spike Protein-Directed Monoclonal Antibodies May Ameliorate COVID-19 Complications in APECED Patients.Frontiers in immunology · 2021Trial
- High risk of hypoxemic COVID-19 pneumonia in myasthenia gravis patients with type I IFN autoantibodies.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Ruxolitinib prevents irreversible autoimmune endocrinopathies in APECED.Nature communications · 2026Article
- Performance of expanded diagnostic criteria for APECED in independent cohorts and implications for earlier diagnosis.JCI insight · 2026Article
- High risk of hypoxemic COVID-19 pneumonia in myasthenia gravis patients with type I IFN autoantibodies.medRxiv : the preprint server for health sciences · 2026Article
- Advances in the Basic Sciences in Thoracic Oncology in the Last 20 Years and Their Translational Impact.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2026Review
- Immune cell subsets in autoimmune polyendocrine syndrome type I.Scientific reports · 2025Article
- Higher density of compact B cell clusters in invasive front may contribute to better prognosis in pancreatic ductal adenocarcinoma.Discover oncology · 2025Article
- Lessons From Prospective Longitudinal Follow-up of a French APECED Cohort.The Journal of clinical endocrinology and metabolism · 2025Observational
- Thymic inborn errors of immunity.The Journal of allergy and clinical immunology · 2025Review
- Consumption of Endogenous Caspase-3 Activates Molecular Theranostic Nanoplatform against Inflammation-Induced Profibrotic Positive Feedback in Pulmonary Fibrosis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Multiomics dissection of human RAG deficiency reveals distinctive patterns of immune dysregulation but a common inflammatory signature.Science immunology · 2025Article
- Bronchiectasis in a patient with Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy: a case report.BMC pulmonary medicine · 2024Article
- Divergent autoantibody and cytokine levels in COVID-19 sepsis patients influence survival.Journal of medical virology · 2024Article
- Phage Immunoprecipitation-Sequencing Reveals CDHR5 Autoantibodies in Select Patients With Interstitial Lung Disease.ACR open rheumatology · 2024Article
- Lymphocyte-Directed Immunomodulation Remits Thymoma-Associated Autoimmune Pneumonitis.Journal of clinical immunology · 2024Article
- The Role of Interferon-γ in Autoimmune Polyendocrine Syndrome Type 1.The New England journal of medicine · 2024Article
- Exploring Chronic Hypocalcemia: Insights into Autoimmune Polyglandular Syndrome Type 1-A Case Study and Literature Review.Journal of clinical medicine · 2024Review
- Immunotherapy for Thymomas and Thymic Carcinomas: Current Status and Future Directions.Cancers · 2024Review
- Human autoantibodies neutralizing type I IFNs: From 1981 to 2023.Immunological reviews · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
37 authors at 18 institutions in 4 countries.
Elise M N FerréFungal Pathogenesis Section, LCIM, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD 20892, USA.ORCID 0000-0002-3285-7768
Timothy J BreakFungal Pathogenesis Section, LCIM, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD 20892, USA.
Peter D BurbeloDental Clinical Research Core, National Institute of Dental and Craniofacial Research (NIDCR), NIH, Bethesda, MD 20892, USA.ORCID 0000-0003-1717-048X
Michael AllgäuerLaboratory of Pathology, Center for Cancer Research, NCI, NIH, Bethesda, MD 20892, USA.ORCID 0000-0003-4518-7887
David E KleinerLaboratory of Pathology, Center for Cancer Research, NCI, NIH, Bethesda, MD 20892, USA.ORCID 0000-0003-3442-4453
Dakai JinRadiology and Imaging Sciences, NIH Clinical Center (CC), NIH, Bethesda, MD 20892, USA.ORCID 0000-0002-4806-2943
Ziyue XuRadiology and Imaging Sciences, NIH Clinical Center (CC), NIH, Bethesda, MD 20892, USA.ORCID 0000-0002-5728-6869
Les R FolioRadiology and Imaging Sciences, NIH Clinical Center (CC), NIH, Bethesda, MD 20892, USA.ORCID 0000-0003-2655-7483
Daniel J MolluraRadiology and Imaging Sciences, NIH Clinical Center (CC), NIH, Bethesda, MD 20892, USA.
Muthulekha SwamydasFungal Pathogenesis Section, LCIM, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD 20892, USA.ORCID 0000-0002-8665-7016
Wenjuan GuBiostatistics Research Branch, Division of Clinical Research (DCR), NIAID, NIH, Bethesda, MD 20892, USA.
Sally HunsbergerBiostatistics Research Branch, Division of Clinical Research (DCR), NIAID, NIH, Bethesda, MD 20892, USA.
Chyi-Chia R LeeLaboratory of Pathology, Center for Cancer Research, NCI, NIH, Bethesda, MD 20892, USA.ORCID 0000-0002-5306-7781
Anamaria BondiciFungal Pathogenesis Section, LCIM, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD 20892, USA.
Kevin W HoffmanDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Jean K LimDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0002-4572-6417
Kerry DobbsImmune Deficiency Genetics Section, LCIM, NIAID, NIH, Bethesda, MD 20892, USA.ORCID 0000-0002-3432-3137
Julie E NiemelaImmunology Service, Department of Laboratory Medicine (DLM), NIH CC, NIH, Bethesda, MD 20892, USA.ORCID 0000-0003-4197-3792
Thomas A FleisherImmunology Service, Department of Laboratory Medicine (DLM), NIH CC, NIH, Bethesda, MD 20892, USA.
Amy P HsuImmunopathogenesis Section, LCIM, NIAID, NIH, Bethesda, MD 20892, USA.ORCID 0000-0001-6841-2122
Laquita N SnowFungal Pathogenesis Section, LCIM, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD 20892, USA.ORCID 0000-0001-8395-0746
Dirk N DarnellFungal Pathogenesis Section, LCIM, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD 20892, USA.
Samar OjaimiDepartment of Infectious Diseases, Monash Health, Melbourne, VIC 3800, Australia.ORCID 0000-0003-2129-1866
Megan A CooperDepartment of Pediatrics, Division of Rheumatology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Martin BozzolaDepartment of Pediatrics, British Hospital, Perdriel 74, CABA-Buenos Aires, Argentina.ORCID 0000-0003-3718-7086
Gary I KleinerUniversity of Miami Department of Pediatrics, Miami, FL 33136, USA.ORCID 0000-0003-2066-9476
Juan C MartinezCystic Fibrosis, Pulmonary, and Sleep Division, Joe DiMaggio Children's Hospital, Hollywood, FL 33021, USA.
Robin R DeterdingDepartment of Pediatrics, University of Colorado Anschutz Medical Campus and Children's Hospital Colorado, Aurora, CO 80045, USA.
Douglas B KuhnsNeutrophil Monitoring Laboratory, Applied/Developmental Research Directorate, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc., Frederick, MD 21701, USA.ORCID 0000-0002-9971-0760
Theo HellerTranslational Hepatology Section, Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892, USA.
Karen K WinerPediatric Growth and Nutrition Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), Bethesda, MD 20892, USA.
Arun RajanThoracic and Gastrointestinal Malignancies Branch, Center for Cancer Research, NCI, NIH, Bethesda, MD 20892, USA.
Steven M HollandImmunopathogenesis Section, LCIM, NIAID, NIH, Bethesda, MD 20892, USA.ORCID 0000-0003-3207-5464
Luigi D NotarangeloImmune Deficiency Genetics Section, LCIM, NIAID, NIH, Bethesda, MD 20892, USA.ORCID 0000-0002-8335-0262
Kevin P FennellyLaboratory of Chronic Airway Infection, Pulmonary Branch, National Heart, Lung, and Blood Institute (NHLBI), Bethesda, MD 20892, USA.
Kenneth N OlivierLaboratory of Chronic Airway Infection, Pulmonary Branch, National Heart, Lung, and Blood Institute (NHLBI), Bethesda, MD 20892, USA.ORCID 0000-0001-8200-255X
Michail S LionakisFungal Pathogenesis Section, LCIM, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD 20892, USA. lionakism@mail.nih.gov.ORCID 0000-0003-4994-9500
National Institute of Allergy and Infectious Diseases · USNational Institutes of Health · USNational Institutes of Health Clinical Center · USCenter for Cancer Research · USIcahn School of Medicine at Mount Sinai · USImmune Deficiency Foundation · USNational Heart Lung and Blood Institute · USChildren's Hospital Colorado · USEunice Kennedy Shriver National Institute of Child Health and Human Development · USHeidelberg University · DEHospital Británico de Buenos Aires · ARJoe DiMaggio Children's Hospital · USLeidos (United States) · USMonash Medical Centre · AUNational Institute of Dental and Craniofacial Research · USNational Institute of Diabetes and Digestive and Kidney Diseases · USUniversity of Miami · USWashington University in St. Louis · US
Funding
Immunopathogenesis of Fungal InfectionsZIAAI001175 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI LIONAKIS, MICHAIL · 2012 to 2025
$23.9MGenes And Gene Products As ImmunoadjuvantsZIAAI000647 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI HOLLAND, STEVEN · 2009 to 2025
$22.6MTransgenic Animal Models Of Human Immune DefectsZIAAI000646 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI HOLLAND, STEVEN · 2009 to 2025
$22.2MLongitudinal Characterization of Respiratory Tract Exacerbations and Treatment Responses in Primary Ciliary DyskinesiaU54HL096458 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVIS, STEPHANIE DUGGINS, FERKOL, THOMAS W · 2009 to 2023
$20.0MCharacterization of the cellular and molecular bases of inborn errors of immunityZIAAI001222 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI NOTARANGELO, LUIGI · 2017 to 2025
$15.2MPostmortem PathologyZICBC010685 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI KLEINER, DAVID ERWIN · 2009 to 2025
$14.3MInvestigation of non-cirrhotic portal hypertension.ZIADK075008 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI HELLER, THEO · 2009 to 2025
$4.5MInflammatory and immune dysregulation associated lung diseaseZIAHL006201 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI OLIVIER, KENNETH · 2015 to 2022
$2.1MCCR NIH HHS HHSN261200800001CIntramural NIH HHS Z99 AI999999NCI NIH HHS HHSN261200800001ENHLBI NIH HHS U54 HL096458
Abstract
Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED), a monogenic disorder caused by
Indexed as
AdolescentAdultAutoantibodiesAutoimmune DiseasesAutoimmunityB-LymphocytesChildChild, PreschoolFemaleHumansInfantInfant, NewbornLymphocytesMaleMiddle AgedPneumoniaAutoantibodies
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.