ArticleDiabetes2019
Targeting BCAA Catabolism to Treat Obesity-Associated Insulin Resistance.
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Article in Diabetes, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 191 papers, 1 of them a synthesis that pooled it.
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191citing papers in PubMed, 1 pooled it
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Who cites it
191 citing papers in PubMed, 1 synthesis or guideline pooled it, 301 citations in OpenAlex.
- Causal role of genetically predicted impairment of branched-chain amino acid catabolism on insulin secretion and insulin resistance in type 2 diabetes.Diabetes, obesity & metabolism · 2026Pooled it
- Effects of healthy low-carbohydrate diet and time-restricted eating on weight and gut microbiome in adults with overweight or obesity: Feeding RCT.Cell reports. Medicine · 2024Trial
- Trial
- A randomized placebo-controlled clinical trial for pharmacological activation of BCAA catabolism in patients with type 2 diabetes.Nature communications · 2022Trial
- Metabolomic effects of androgen deprivation therapy treatment for prostate cancer.Cancer medicine · 2020Trial
- Essential Amino Acid Supplement Lowers Intrahepatic Lipid despite Excess Alcohol Consumption.Nutrients · 2020Trial
- Article
- Gut microbiota metabolic reprogramming drives the development of metabolic diseases in the host.Gut microbes · 2026Review
- The emerging role of branched-chain amino acid metabolism in obesity.International journal of obesity (2005) · 2026Review
- Commentary: Unveiling a Metabolic-Lymphatic Axis in the Pathogenesis of Heart Failure With Preserved Ejection Fraction.Cardiology discovery · 2026Article
- Exercise Resistance in Obese Male NZO Mice Manifests as Local Muscle Remodelling Without Glycaemic Improvements.Diabetes, obesity & metabolism · 2026Article
- Amino Acid Metabolism in Health and Disease.MedComm · 2026Review
- Association of BCAAs/BCKAs with pancreatic steatosis in patients with type 2 diabetes mellitus: A cross-sectional study.Journal of diabetes investigation · 2026Article
- Metabolite and nutrient regulation of macrophages in obesity and metabolic disease.Nature reviews. Immunology · 2026Review
- Stress-coping phenotypes shape adipose tissue function and plasticity and modulate metabolic resilience.Translational psychiatry · 2026Article
- The Role of Precision Nutrition in Kidney Disease.Clinical journal of the American Society of Nephrology : CJASN · 2026Review
- Screening of metabolic-related biomarkers linking intervertebral disc degeneration and type 2 diabetes based on comprehensive bioinformatics analysis and machine learning.Biochemistry and biophysics reports · 2026Article
- Metabolomic Pathways Distinguishing Metabolically Healthy and Unhealthy Obesity from Normal-Weight: A Cross-Sectional Study.International journal of molecular sciences · 2026Article
- Defective branched-chain amino acid catabolism promotes pulmonary fibrosis by inducing apoptosis resistance of myofibroblasts in mice.Cell communication and signaling : CCS · 2026Article
- Article
131 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
20 authors at 4 institutions in 2 countries.
Meiyi ZhouDepartment of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of the Chinese Ministry of Education, Hongqiao International Institute of Medicine, Shanghai Tongren Hospital/Faculty of Basic Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jing ShaoDepartment of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of the Chinese Ministry of Education, Hongqiao International Institute of Medicine, Shanghai Tongren Hospital/Faculty of Basic Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Cheng-Yang WuDepartment of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX.
Le ShuDepartment of Integrative Biology and Physiology, University of California at Los Angeles, Los Angeles, CA.
Weibing DongDepartment of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of the Chinese Ministry of Education, Hongqiao International Institute of Medicine, Shanghai Tongren Hospital/Faculty of Basic Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yunxia LiuDepartment of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of the Chinese Ministry of Education, Hongqiao International Institute of Medicine, Shanghai Tongren Hospital/Faculty of Basic Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Mengping ChenDepartment of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of the Chinese Ministry of Education, Hongqiao International Institute of Medicine, Shanghai Tongren Hospital/Faculty of Basic Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
R Max WynnDepartment of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX.ORCID 0000-0002-1879-2136
Jiqiu WangDepartment of Endocrinology and Metabolism, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Ji WangDepartment of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of the Chinese Ministry of Education, Hongqiao International Institute of Medicine, Shanghai Tongren Hospital/Faculty of Basic Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Wen-Jun GuiDepartment of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX.
Xiangbing QiChemistry Center, National Institute of Biological Science, Beijing, China.
Aldons J LusisDepartments of Medicine, Microbiology, and Human Genetics, University of California at Los Angeles, Los Angeles, CA.ORCID 0000-0001-9013-0228
Zhaoping LiDepartment of Clinical Nutrition, University of California at Los Angeles, Los Angeles, CA.
Weiqing WangDepartment of Endocrinology and Metabolism, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Guang NingDepartment of Endocrinology and Metabolism, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xia YangDepartment of Integrative Biology and Physiology, University of California at Los Angeles, Los Angeles, CA.ORCID 0000-0002-3971-038X
David T ChuangDepartment of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX.ORCID 0000-0002-3640-8927
Yibin WangDepartments of Anesthesiology, Medicine, and Physiology, University of California at Los Angeles, Los Angeles, CA.
Haipeng SunDepartment of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of the Chinese Ministry of Education, Hongqiao International Institute of Medicine, Shanghai Tongren Hospital/Faculty of Basic Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, China sun.haipeng@yahoo.com.ORCID 0000-0003-2128-3209
Shanghai Jiao Tong University · CNUniversity of California, Los Angeles · USThe University of Texas Southwestern Medical Center · USNational Institute of Biological Sciences, Beijing · CN
Funding
ROLE OF P38 MAPK AND PP2C IN ISCHEMIC INJURY AND PROTECTIONP01HL080111 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WEISS, JAMES N · 2005 to 2009
$11.6MStructure and Function of Mitochondrial Protein KinasesR01DK062306 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI CHUANG, DAVID T · 2003 to 2018
$5.4MNovel Signaling Mechanisms and Molecular Targets in the Stressed MyocardiumR01HL098954 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PING, PEIPEI, WANG, YIBIN · 2010 to 2013
$3.0MDHA Reverses Gene Network Signatures of Fructose-induced Metabolic SyndromeR01DK104363 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI YANG, XIA · 2015 to 2019
$2.4MNovel Mechanism of SR Calcium Regulation in Cardiac DysfunctionR01HL108186 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WANG, YIBIN · 2011 to 2015
$1.9MNovel Function and Regulatory Mechanisms of Stress Kinase p38 in HeartR01HL103205 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WANG, YIBIN · 2010 to 2014
$1.9MBCAA Catabolic Defect in HF: Novel Mechanism and Therapeutic TargetR01HL140116 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LI, ZHAOPING · 2018 to 2021
$1.6MStructure and Function of Mitochondrial Protein KinasesR56DK062306 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI CHUANG, DAVID T · 2008 to 2014
$397kNHLBI NIH HHS P01 HL080111NHLBI NIH HHS R01 HL098954NHLBI NIH HHS R01 HL103205NHLBI NIH HHS R01 HL108186NHLBI NIH HHS R01 HL140116NIDDK NIH HHS R01 DK062306NIDDK NIH HHS R01 DK104363NIDDK NIH HHS R56 DK062306
Abstract
Recent studies implicate a strong association between elevated plasma branched-chain amino acids (BCAAs) and insulin resistance (IR). However, a causal relationship and whether interrupted BCAA homeostasis can serve as a therapeutic target for diabetes remain to be established experimentally. In this study, unbiased integrative pathway analyses identified a unique genetic link between obesity-associated IR and BCAA catabolic gene expression at the pathway level in human and mouse populations. In genetically obese (
Indexed as
Amino Acids, Branched-ChainAnimalsDiet, High-FatGene ExpressionGenome-Wide Association StudyGlucose Tolerance TestHumansInsulinInsulin ResistanceMaleMechanistic Target of Rapamycin Complex 1MetabolomeMiceObesityProtein KinasesSignal Transduction(3-methyl-2-oxobutanoate dehydrogenase (lipoamide)) kinaseAmino Acids, Branched-ChainInsulinMechanistic Target of Rapamycin Complex 1Protein Kinases
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.