Evidence map›Paper›PMID 31167818›Full record

Trial reportBlood advances2019

Postrelapse survival in diffuse large B-cell lymphoma after therapy failure following autologous transplantation.

Narendranath Epperla, Talha Badar, Aniko Szabo, John Vaughn, Steve Borson, Neeraj Y Saini, Romil D Patel, Nirav N Shah, Mehdi Hamadani, Sairah Ahmed and 2 more

Open access · goldAbstract readClinical TrialMulticenter Study
In one paragraph

Trial report in Blood advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 39 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Narendranath EpperlaDivision of Hematology, The James Cancer Hospital and Solove Research Institute, The Ohio State University, Columbus, OH.ORCID 0000-0002-8216-3457
Talha BadarDivision of Hematology and Oncology, Medical College of Wisconsin, Milwaukee, WI.ORCID 0000-0003-1548-918X
Aniko SzaboDivision of Hematology and Oncology, Medical College of Wisconsin, Milwaukee, WI.ORCID 0000-0002-8129-0614
John VaughnDivision of Hematology, The James Cancer Hospital and Solove Research Institute, The Ohio State University, Columbus, OH.
Steve BorsonDivision of Hematology, Washington University School of Medicine, St. Louis, MO; and.
Neeraj Y SainiDepartment of Stem Cell Transplant and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX.
Romil D PatelDepartment of Stem Cell Transplant and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX.
Nirav N ShahDivision of Hematology and Oncology, Medical College of Wisconsin, Milwaukee, WI.
Mehdi HamadaniDivision of Hematology and Oncology, Medical College of Wisconsin, Milwaukee, WI.ORCID 0000-0001-5372-510X
Sairah AhmedDepartment of Stem Cell Transplant and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX.
Amanda F CashenDivision of Hematology, Washington University School of Medicine, St. Louis, MO; and.
Timothy S FenskeDivision of Hematology and Oncology, Medical College of Wisconsin, Milwaukee, WI.
Medical College of Wisconsin · USThe University of Texas MD Anderson Cancer Center · USThe Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute · USWashington University in St. Louis · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Outcomes for diffuse large B-cell lymphoma (DLBCL) patients relapsing after autologous hematopoietic cell transplantation (auto-HCT) have been historically poor. We studied outcomes of such patients using data from 4 transplantation centers. Eligibility criteria included adult patients (age ≥18 years) with DLBCL experiencing disease relapse after auto-HCT performed during 2006 to 2015. The time period was stratified into 2 eras (era 1, 2006-2010; era 2, 2011-2015). The primary end point was postrelapse overall survival (PR-OS). Secondary end points were factors prognostic of PR-OS. Of the 700 patients with DLBCL who underwent auto-HCT, 248 (35%) relapsed after auto-HCT. Median PR-OS of all relapsed DLBCL patients after auto-HCT (n = 228) was 9.8 months (95% confidence interval [CI], 7-15). Median PR-OS was significantly better for patients in complete (17.8 months; 95% CI, 7.9-41.6) vs partial remission at auto-HCT (7.1 months; 95% CI, 5.4-11;

Indexed as

Hematopoietic Stem Cell TransplantationAdultAgedAutograftsDisease-Free SurvivalFemaleHumansLymphoma, Large B-Cell, DiffuseMaleMiddle AgedSurvival RateTime Factors

Identifiers

PMID31167818
PMCPMC6560348
OpenAlexW2948517706

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.